APOH [The Human Chemical-Genetic Interaction Map Project]

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======= APOH =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: APOH
  * **<color #00a2e8>Official Name</color>**: apolipoprotein H
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=350|350]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P02749|P02749]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=APOH&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20APOH|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/138700|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies.  APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sushi 2|
|Sushi|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lipoprotein lipase activator activity|
|triglyceride transport|
|acylglycerol transport|
|negative regulation of smooth muscle cell apoptotic process|
|positive regulation of lipoprotein lipase activity|
|positive regulation of triglyceride lipase activity|
|negative regulation of fibrinolysis|
|plasminogen activation|
|chylomicron|
|platelet dense granule lumen|
|regulation of fibrinolysis|
|negative regulation of myeloid cell apoptotic process|
|blood coagulation, intrinsic pathway|
|very-low-density lipoprotein particle|
|regulation of lipoprotein lipase activity|
|high-density lipoprotein particle|
|regulation of smooth muscle cell apoptotic process|
|positive regulation of blood coagulation|
|protein activation cascade|
|blood coagulation, fibrin clot formation|
|positive regulation of hemostasis|
|positive regulation of coagulation|
|regulation of myeloid cell apoptotic process|
|negative regulation of endothelial cell proliferation|
|negative regulation of muscle cell apoptotic process|
|zymogen activation|
|negative regulation of endothelial cell migration|
|negative regulation of blood coagulation|
|negative regulation of hemostasis|
|negative regulation of coagulation|
|positive regulation of wound healing|
|positive regulation of response to wounding|
|negative regulation of epithelial cell migration|
|regulation of muscle cell apoptotic process|
|positive regulation of lipase activity|
|negative regulation of wound healing|
|triglyceride metabolic process|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of coagulation|
|negative regulation of response to wounding|
|regulation of lipase activity|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|phospholipid binding|
|negative regulation of vasculature development|
|negative regulation of epithelial cell proliferation|
|platelet degranulation|
|regulation of endothelial cell proliferation|
|regulation of wound healing|
|lipid binding|
|regulation of endothelial cell migration|
|protein processing|
|regulation of response to wounding|
|heparin binding|
|regulation of epithelial cell migration|
|protein maturation|
|negative regulation of cell migration|
|negative regulation of cell motility|
|regulation of angiogenesis|
|blood coagulation|
|coagulation|
|lipid transport|
|hemostasis|
|negative regulation of cellular component movement|
|lipid localization|
|regulation of vasculature development|
|negative regulation of locomotion|
|regulation of epithelial cell proliferation|
|negative regulation of response to external stimulus|
|collagen-containing extracellular matrix|
|glycerolipid metabolic process|
|wound healing|
|regulation of body fluid levels|
|response to wounding|
|positive regulation of response to external stimulus|
|cell surface|
|negative regulation of cell population proliferation|
|regulated exocytosis|
|positive regulation of hydrolase activity|
|exocytosis|
|regulation of cell migration|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cell motility|
|negative regulation of developmental process|
|cellular lipid metabolic process|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cell death|
|secretion by cell|
|export from cell|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|regulation of response to external stimulus|
|secretion|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|proteolysis|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|regulation of response to stress|
|regulation of apoptotic process|
|regulation of programmed cell death|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|extracellular region|
|vesicle-mediated transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-1.93|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.71|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.71|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|1.84|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15782
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='APOH Expression in NALM6 Cells: -0.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>