APOL2 [The Human Chemical-Genetic Interaction Map Project]

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======= APOL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: APOL2
  * **<color #00a2e8>Official Name</color>**: apolipoprotein L2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23780|23780]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BQE5|Q9BQE5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=APOL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20APOL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607252|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ApoL|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|high-density lipoprotein particle binding|
|acute-phase response|
|maternal process involved in female pregnancy|
|acute inflammatory response|
|cholesterol metabolic process|
|lipoprotein metabolic process|
|secondary alcohol metabolic process|
|sterol metabolic process|
|lipid binding|
|female pregnancy|
|multi-multicellular organism process|
|steroid metabolic process|
|lipid transport|
|alcohol metabolic process|
|lipid localization|
|signaling receptor binding|
|organic hydroxy compound metabolic process|
|inflammatory response|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|endoplasmic reticulum membrane|
|multi-organism reproductive process|
|lipid metabolic process|
|defense response|
|reproductive process|
|reproduction|
|small molecule metabolic process|
|extracellular region|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12921
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='APOL2 Expression in NALM6 Cells: 4.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>