AQP3 [The Human Chemical-Genetic Interaction Map Project]

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======= AQP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AQP3
  * **<color #00a2e8>Official Name</color>**: aquaporin 3 (Gill blood group)
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=360|360]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92482|Q92482]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AQP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AQP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600170|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].  Sequence Note: This RefSeq record represents the AQP3*001.1.1 allele. 
  * **<color #00a2e8>UniProt Summary</color>**:  Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MIP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|renal water absorption|
|glycerol channel activity|
|renal water transport|
|glycerol transport|
|cellular response to oxygen-glucose deprivation|
|urea transmembrane transporter activity|
|urea transmembrane transport|
|response to oxygen-glucose deprivation|
|urea transport|
|polyol transport|
|water channel activity|
|renal absorption|
|one-carbon compound transport|
|water transport|
|fluid transport|
|response to vitamin D|
|renal water homeostasis|
|regulation of keratinocyte differentiation|
|regulation of epidermal cell differentiation|
|multicellular organismal water homeostasis|
|water homeostasis|
|carbohydrate transport|
|regulation of epidermis development|
|response to vitamin|
|response to retinoic acid|
|renal system process|
|odontogenesis|
|organic hydroxy compound transport|
|regulation of epithelial cell differentiation|
|response to calcium ion|
|cell-cell junction|
|cellular response to hypoxia|
|basolateral plasma membrane|
|cellular response to decreased oxygen levels|
|response to nutrient|
|cellular response to oxygen levels|
|cellular response to nutrient levels|
|cellular response to extracellular stimulus|
|multicellular organismal homeostasis|
|cellular response to external stimulus|
|response to hypoxia|
|response to acid chemical|
|response to decreased oxygen levels|
|response to metal ion|
|response to oxygen levels|
|regulation of body fluid levels|
|response to nutrient levels|
|response to extracellular stimulus|
|response to inorganic substance|
|response to lipid|
|response to organic cyclic compound|
|animal organ morphogenesis|
|chemical homeostasis|
|positive regulation of immune system process|
|response to abiotic stimulus|
|transmembrane transport|
|response to oxygen-containing compound|
|amide transport|
|homeostatic process|
|regulation of immune system process|
|cellular response to stress|
|regulation of cell differentiation|
|nitrogen compound transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12378
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AQP3 Expression in NALM6 Cells: -1.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>