ARG1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= ARG1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARG1
  * **<color #00a2e8>Official Name</color>**: arginase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=383|383]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P05089|P05089]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARG1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARG1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608313|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. {ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Arginase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of neutrophil mediated killing of fungus|
|positive regulation of neutrophil mediated killing of fungus|
|arginine catabolic process to ornithine|
|regulation of L-arginine import|
|regulation of defense response to fungus|
|positive regulation of neutrophil mediated cytotoxicity|
|arginase activity|
|positive regulation of neutrophil mediated killing of symbiont cell|
|regulation of neutrophil mediated killing of symbiont cell|
|negative regulation of T-helper 2 cell cytokine production|
|regulation of neutrophil mediated cytotoxicity|
|mammary gland involution|
|response to methylmercury|
|negative regulation of response to interferon-gamma|
|negative regulation of interferon-gamma-mediated signaling pathway|
|negative regulation of T cell cytokine production|
|collagen biosynthetic process|
|ornithine metabolic process|
|arginine catabolic process|
|negative regulation of activated T cell proliferation|
|response to selenium ion|
|urea cycle|
|regulation of T-helper 2 cell cytokine production|
|urea metabolic process|
|response to vitamin E|
|nitrogen cycle metabolic process|
|response to herbicide|
|negative regulation of type 2 immune response|
|positive regulation of killing of cells of other organism|
|regulation of killing of cells of other organism|
|arginine metabolic process|
|response to vitamin A|
|negative regulation of T cell mediated immunity|
|response to manganese ion|
|defense response to protozoan|
|response to protozoan|
|negative regulation of cytokine production involved in immune response|
|regulation of response to interferon-gamma|
|regulation of interferon-gamma-mediated signaling pathway|
|cellular response to glucagon stimulus|
|glutamine family amino acid catabolic process|
|cellular response to interleukin-4|
|cellular response to dexamethasone stimulus|
|regulation of type 2 immune response|
|positive regulation of myeloid leukocyte mediated immunity|
|regulation of amino acid transport|
|regulation of T cell cytokine production|
|response to interleukin-4|
|protein homotrimerization|
|negative regulation of production of molecular mediator of immune response|
|response to glucagon|
|regulation of activated T cell proliferation|
|negative regulation of lymphocyte mediated immunity|
|negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|response to dexamethasone|
|mammary gland morphogenesis|
|negative regulation of adaptive immune response|
|response to amine|
|response to axon injury|
|negative regulation of leukocyte mediated immunity|
|protein trimerization|
|response to zinc ion|
|positive regulation of leukocyte mediated cytotoxicity|
|negative regulation of innate immune response|
|cellular response to glucocorticoid stimulus|
|regulation of myeloid leukocyte mediated immunity|
|regulation of organic acid transport|
|cellular response to corticosteroid stimulus|
|negative regulation of T cell proliferation|
|negative regulation of cytokine-mediated signaling pathway|
|specific granule lumen|
|manganese ion binding|
|response to cadmium ion|
|maternal process involved in female pregnancy|
|negative regulation of response to cytokine stimulus|
|collagen metabolic process|
|positive regulation of cell killing|
|glutamine family amino acid metabolic process|
|regulation of T cell mediated immunity|
|cellular response to hydrogen peroxide|
|negative regulation of mononuclear cell proliferation|
|negative regulation of lymphocyte proliferation|
|regulation of leukocyte mediated cytotoxicity|
|negative regulation of leukocyte proliferation|
|regulation of cytokine production involved in immune response|
|response to vitamin|
|azurophil granule lumen|
|cellular response to ketone|
|negative regulation of response to biotic stimulus|
|positive regulation of endothelial cell proliferation|
|regulation of amine transport|
|response to antineoplastic agent|
|regulation of anion transport|
|regulation of response to drug|
|gland morphogenesis|
|tissue remodeling|
|regulation of cell killing|
|alpha-amino acid catabolic process|
|negative regulation of T cell activation|
|response to amino acid|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|negative regulation of immune effector process|
|negative regulation of leukocyte cell-cell adhesion|
|liver development|
|cellular amino acid catabolic process|
|mammary gland development|
|regulation of endothelial cell proliferation|
|hepaticobiliary system development|
|cellular response to reactive oxygen species|
|positive regulation of leukocyte mediated immunity|
|regulation of production of molecular mediator of immune response|
|response to glucocorticoid|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of lymphocyte activation|
|negative regulation of immune response|
|regulation of lymphocyte mediated immunity|
|cellular response to transforming growth factor beta stimulus|
|regulation of T cell proliferation|
|regulation of adaptive immune response|
|response to corticosteroid|
|response to transforming growth factor beta|
|mitochondrial outer membrane|
|regulation of cytokine-mediated signaling pathway|
|lung development|
|respiratory tube development|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|regulation of response to cytokine stimulus|
|female pregnancy|
|cellular response to lipopolysaccharide|
|cellular response to xenobiotic stimulus|
|cellular response to steroid hormone stimulus|
|positive regulation of epithelial cell proliferation|
|cellular response to molecule of bacterial origin|
|response to ketone|
|response to reactive oxygen species|
|respiratory system development|
|negative regulation of cell activation|
|regulation of leukocyte mediated immunity|
|negative regulation of defense response|
|regulation of lymphocyte proliferation|
|alpha-amino acid metabolic process|
|regulation of mononuclear cell proliferation|
|multi-multicellular organism process|
|cellular response to toxic substance|
|cellular response to biotic stimulus|
|response to nutrient|
|negative regulation of multi-organism process|
|positive regulation of immune effector process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of leukocyte proliferation|
|cellular response to oxidative stress|
|carboxylic acid catabolic process|
|cellular response to peptide hormone stimulus|
|organic acid catabolic process|
|negative regulation of cell adhesion|
|negative regulation of cytokine production|
|aging|
|regulation of leukocyte cell-cell adhesion|
|response to xenobiotic stimulus|
|response to antibiotic|
|cellular amino acid metabolic process|
|response to lipopolysaccharide|
|regulation of T cell activation|
|neuron projection|
|cellular response to peptide|
|response to molecule of bacterial origin|
|response to steroid hormone|
|regulation of epithelial cell proliferation|
|protein homooligomerization|
|response to acid chemical|
|positive regulation of response to biotic stimulus|
|negative regulation of response to external stimulus|
|response to metal ion|
|neuronal cell body|
|response to oxidative stress|
|response to peptide hormone|
|regulation of cell-cell adhesion|
|cellular response to drug|
|gland development|
|small molecule catabolic process|
|negative regulation of immune system process|
|regulation of innate immune response|
|regulation of immune effector process|
|response to peptide|
|positive regulation of defense response|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|response to nutrient levels|
|neutrophil mediated immunity|
|cellular response to growth factor stimulus|
|neutrophil activation|
|granulocyte activation|
|response to toxic substance|
|positive regulation of multi-organism process|
|leukocyte degranulation|
|regulation of lymphocyte activation|
|myeloid leukocyte mediated immunity|
|protein complex oligomerization|
|cellular response to lipid|
|myeloid cell activation involved in immune response|
|regulation of response to biotic stimulus|
|amide biosynthetic process|
|response to extracellular stimulus|
|response to growth factor|
|response to inorganic substance|
|cellular response to organic cyclic compound|
|response to wounding|
|myeloid leukocyte activation|
|cellular response to organonitrogen compound|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|cellular response to hormone stimulus|
|adaptive immune response|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|cellular response to nitrogen compound|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|regulation of ion transport|
|regulated exocytosis|
|regulation of defense response|
|leukocyte mediated immunity|
|innate immune response|
|regulation of multi-organism process|
|cellular amide metabolic process|
|exocytosis|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|tube development|
|response to lipid|
|carboxylic acid metabolic process|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|leukocyte activation|
|defense response to other organism|
|animal organ morphogenesis|
|multi-organism reproductive process|
|response to organonitrogen compound|
|oxoacid metabolic process|
|secretion by cell|
|cellular response to cytokine stimulus|
|response to drug|
|organic acid metabolic process|
|export from cell|
|cellular response to oxygen-containing compound|
|organonitrogen compound catabolic process|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|secretion|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|regulation of response to stress|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|regulation of immune system process|
|cellular response to stress|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.95|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4512
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.19 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARG1 Expression in NALM6 Cells: -1.19'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>