ARG2 [The Human Chemical-Genetic Interaction Map Project]

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======= ARG2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARG2
  * **<color #00a2e8>Official Name</color>**: arginase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=384|384]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P78540|P78540]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARG2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARG2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/107830|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:   Arginase catalyzes the hydrolysis of arginine to ornithine and urea.  At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function.  The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney.  The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism.  Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells (PubMed:27745970). May suppress inflammation-related signaling in asthmatic airway epithelium (PubMed:27214549). May contribute to the immune evasion of H.pylori by restricting M1 macrophage activation and polyamine metabolism (By similarity). In fetal dendritic cells may play a role in promoting immune suppression and T cell TNF-alpha production during gestation (PubMed:28614294). Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction (PubMed:22928666). Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling (PubMed:25484082). Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity (PubMed:23832324). Since NOS is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase-2 plays a role in both male and female sexual arousal (PubMed:12859189). {ECO:0000250|UniProtKB:O08691, ECO:0000269|PubMed:12859189, ECO:0000269|PubMed:22928666, ECO:0000269|PubMed:23832324, ECO:0000269|PubMed:25484082, ECO:0000269|PubMed:27214549, ECO:0000269|PubMed:27745970}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Arginase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process|
|regulation of chemokine (C-C motif) ligand 4 production|
|negative regulation of chemokine (C-C motif) ligand 4 production|
|regulation of activated CD8-positive, alpha-beta T cell apoptotic process|
|arginine catabolic process to ornithine|
|arginase activity|
|negative regulation of interleukin-17 secretion|
|negative regulation of macrophage inflammatory protein 1 alpha production|
|negative regulation of chemokine (C-C motif) ligand 5 production|
|negative regulation of interleukin-13 secretion|
|regulation of interleukin-17 secretion|
|regulation of macrophage inflammatory protein 1 alpha production|
|negative regulation of defense response to bacterium|
|negative regulation of interleukin-13 production|
|negative regulation of CD4-positive, alpha-beta T cell proliferation|
|regulation of chemokine (C-C motif) ligand 5 production|
|negative regulation of tumor necrosis factor secretion|
|ornithine metabolic process|
|regulation of interleukin-13 secretion|
|arginine catabolic process|
|negative regulation of alpha-beta T cell proliferation|
|regulation of CD4-positive, alpha-beta T cell proliferation|
|urea cycle|
|urea metabolic process|
|nitric oxide biosynthetic process|
|nitrogen cycle metabolic process|
|negative regulation of type 2 immune response|
|positive regulation of cellular senescence|
|negative regulation of interleukin-17 production|
|positive regulation of cell aging|
|nitric oxide metabolic process|
|arginine metabolic process|
|negative regulation of T cell apoptotic process|
|regulation of defense response to bacterium|
|negative regulation of chemokine production|
|reactive nitrogen species metabolic process|
|regulation of interleukin-13 production|
|reactive oxygen species biosynthetic process|
|glutamine family amino acid catabolic process|
|negative regulation of lymphocyte apoptotic process|
|regulation of tumor necrosis factor secretion|
|negative regulation of CD4-positive, alpha-beta T cell activation|
|regulation of interleukin-17 production|
|regulation of type 2 immune response|
|regulation of alpha-beta T cell proliferation|
|regulation of T cell apoptotic process|
|negative regulation of alpha-beta T cell activation|
|regulation of cellular senescence|
|neurotransmitter biosynthetic process|
|negative regulation of leukocyte apoptotic process|
|regulation of interleukin-1 beta secretion|
|regulation of cell aging|
|regulation of lymphocyte apoptotic process|
|regulation of interleukin-1 secretion|
|negative regulation of tumor necrosis factor production|
|regulation of CD4-positive, alpha-beta T cell activation|
|negative regulation of T cell proliferation|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|manganese ion binding|
|negative regulation of cytokine secretion|
|glutamine family amino acid metabolic process|
|negative regulation of mononuclear cell proliferation|
|negative regulation of lymphocyte proliferation|
|regulation of chemokine production|
|negative regulation of leukocyte proliferation|
|regulation of interleukin-1 beta production|
|regulation of leukocyte apoptotic process|
|regulation of reactive oxygen species biosynthetic process|
|ureteric bud development|
|mesonephric epithelium development|
|mesonephric tubule development|
|neurotransmitter metabolic process|
|mesonephros development|
|negative regulation of response to biotic stimulus|
|regulation of alpha-beta T cell activation|
|regulation of interleukin-1 production|
|alpha-amino acid catabolic process|
|striated muscle contraction|
|negative regulation of T cell activation|
|reactive oxygen species metabolic process|
|negative regulation of leukocyte cell-cell adhesion|
|cellular amino acid catabolic process|
|kidney epithelium development|
|negative regulation of protein secretion|
|negative regulation of peptide secretion|
|negative regulation of lymphocyte activation|
|negative regulation of immune response|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|regulation of T cell proliferation|
|negative regulation of leukocyte activation|
|negative regulation of cell-cell adhesion|
|regulation of reactive oxygen species metabolic process|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|negative regulation of cell activation|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|negative regulation of defense response|
|regulation of lymphocyte proliferation|
|alpha-amino acid metabolic process|
|regulation of mononuclear cell proliferation|
|negative regulation of multi-organism process|
|regulation of leukocyte proliferation|
|negative regulation of secretion|
|muscle contraction|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|kidney development|
|negative regulation of cell adhesion|
|negative regulation of cytokine production|
|renal system development|
|regulation of leukocyte cell-cell adhesion|
|muscle system process|
|cellular amino acid metabolic process|
|regulation of T cell activation|
|urogenital system development|
|regulation of neurotransmitter levels|
|negative regulation of response to external stimulus|
|mitochondrial matrix|
|regulation of cell-cell adhesion|
|small molecule catabolic process|
|negative regulation of immune system process|
|regulation of protein secretion|
|negative regulation of transport|
|regulation of peptide secretion|
|drug metabolic process|
|regulation of lymphocyte activation|
|regulation of response to biotic stimulus|
|amide biosynthetic process|
|regulation of leukocyte activation|
|adaptive immune response|
|regulation of cell activation|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|cellular amide metabolic process|
|regulation of secretion|
|tube development|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|carboxylic acid metabolic process|
|defense response to other organism|
|negative regulation of cell death|
|oxoacid metabolic process|
|organic acid metabolic process|
|regulation of protein localization|
|organonitrogen compound catabolic process|
|regulation of response to external stimulus|
|epithelium development|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|mitochondrion|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|organonitrogen compound biosynthetic process|
|regulation of response to stress|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|regulation of immune system process|
|regulation of cell death|
|small molecule metabolic process|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of transport|
|immune response|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-1.74|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.78|
|[[:results:exp285|GW501516 25μM R06 exp285]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7874
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.25 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARG2 Expression in NALM6 Cells: 2.25'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>