ARGLU1 [The Human Chemical-Genetic Interaction Map Project]

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======= ARGLU1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARGLU1
  * **<color #00a2e8>Official Name</color>**: arginine and glutamate rich 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55082|55082]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NWB6|Q9NWB6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARGLU1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARGLU1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614046|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1. {ECO:0000269|PubMed:21454576}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cadherin binding|
|mitochondrion|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-1.91|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.72|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|1.73|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|1.87|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|1.9|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|1.96|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|1.98|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.07|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.25|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|2.37|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|2.44|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|2.48|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 200/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|11/28|
|blood|12/28|
|bone|8/26|
|breast|12/33|
|central nervous system|14/56|
|cervix|2/4|
|colorectal|6/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|5/16|
|kidney|5/21|
|liver|6/20|
|lung|21/75|
|lymphocyte|4/16|
|ovary|8/26|
|pancreas|5/24|
|peripheral nervous system|2/16|
|plasma cell|5/15|
|prostate|1/1|
|skin|10/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|3/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 394
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.82 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARGLU1 Expression in NALM6 Cells: 8.82'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>