ARHGDIA [The Human Chemical-Genetic Interaction Map Project]

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======= ARHGDIA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARHGDIA
  * **<color #00a2e8>Official Name</color>**: Rho GDP dissociation inhibitor alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=396|396]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P52565|P52565]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARHGDIA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARHGDIA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601925|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. {ECO:0000269|PubMed:20400958, ECO:0000269|PubMed:23434736}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rho GDI|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Rho GDP-dissociation inhibitor activity|
|regulation of actin cytoskeleton reorganization|
|semaphorin-plexin signaling pathway|
|Rac GTPase binding|
|negative regulation of axonogenesis|
|Rho protein signal transduction|
|positive regulation of axonogenesis|
|negative regulation of cell morphogenesis involved in differentiation|
|regulation of Rho protein signal transduction|
|negative regulation of neuron projection development|
|positive regulation of cell morphogenesis involved in differentiation|
|negative regulation of cell projection organization|
|regulation of axonogenesis|
|negative regulation of neuron differentiation|
|regulation of Ras protein signal transduction|
|Ras protein signal transduction|
|negative regulation of cell adhesion|
|positive regulation of neuron projection development|
|GTPase activator activity|
|negative regulation of neurogenesis|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of nervous system development|
|small GTPase mediated signal transduction|
|negative regulation of cell development|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|cytoskeleton|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|regulation of actin filament-based process|
|positive regulation of GTPase activity|
|positive regulation of neurogenesis|
|regulation of GTPase activity|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|positive regulation of nervous system development|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|regulation of neuron differentiation|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|positive regulation of hydrolase activity|
|regulation of neurogenesis|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|negative regulation of cell death|
|regulation of anatomical structure morphogenesis|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|regulation of organelle organization|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|generation of neurons|
|regulation of apoptotic process|
|regulation of programmed cell death|
|neurogenesis|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5561
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARHGDIA Expression in NALM6 Cells: 7.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>