ARIH1 [The Human Chemical-Genetic Interaction Map Project]

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======= ARIH1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARIH1
  * **<color #00a2e8>Official Name</color>**: ariadne RBR E3 ubiquitin protein ligase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25820|25820]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y4X5|Q9Y4X5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARIH1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARIH1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605624|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin- conjugating enzyme E2 UBE2L3 (PubMed:15236971, PubMed:21532592, PubMed:24076655, PubMed:27565346, PubMed:23707686). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets (PubMed:27565346). The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2 (PubMed:27565346). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin- RING ubiquitin ligase complexes (PubMed:24076655, PubMed:27565346). Plays a role in protein translation in response to DNA damage by mediating ubiquitination of EIF4E2, the consequences of EIF4E2 ubiquitination are however unclear (PubMed:25624349). According to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest (PubMed:25624349). According to another report EIF4E2 ubiquitination leads to its subsequent degradation (PubMed:14623119). Acts as the ligase involved in ISGylation of EIF4E2 (PubMed:17289916). {ECO:0000269|PubMed:14623119, ECO:0000269|PubMed:15236971, ECO:0000269|PubMed:17289916, ECO:0000269|PubMed:21532592, ECO:0000269|PubMed:23707686, ECO:0000269|PubMed:24076655, ECO:0000269|PubMed:25624349, ECO:0000269|PubMed:27565346}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IBR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Lewy body|
|ubiquitin-like protein transferase activity|
|Cul4A-RING E3 ubiquitin ligase complex|
|Cul2-RING ubiquitin ligase complex|
|ubiquitin conjugating enzyme binding|
|Cul3-RING ubiquitin ligase complex|
|Cajal body|
|SCF ubiquitin ligase complex|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|positive regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of proteasomal protein catabolic process|
|ubiquitin ligase complex|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|positive regulation of cellular protein catabolic process|
|regulation of ubiquitin-dependent protein catabolic process|
|regulation of proteasomal protein catabolic process|
|positive regulation of protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|ubiquitin protein ligase activity|
|ubiquitin-protein transferase activity|
|regulation of cellular protein catabolic process|
|nuclear body|
|ubiquitin protein ligase binding|
|protein polyubiquitination|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|regulation of protein catabolic process|
|positive regulation of catabolic process|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|protein ubiquitination|
|regulation of proteolysis|
|protein modification by small protein conjugation|
|regulation of cellular catabolic process|
|zinc ion binding|
|cellular macromolecule catabolic process|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|proteolysis|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-3.02|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-2.69|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|-2.42|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-2.32|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.02|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|-2.02|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.02|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-1.93|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.93|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-1.86|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.83|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.82|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-1.82|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-1.79|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|-1.77|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-1.76|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-1.75|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-1.74|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.73|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.8|
|[[:results:exp59|UMK57 1μM R01 exp59]]|3.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mapk14|MAPK14]]|0.469|
|[[:human genes:u:ube2l3|UBE2L3]]|0.457|
|[[:human genes:c:ccdc101|CCDC101]]|0.445|
|[[:human genes:a:atf7ip|ATF7IP]]|0.433|
|[[:human genes:c:cbfb|CBFB]]|0.423|
|[[:human genes:m:mllt1|MLLT1]]|0.416|
|[[:human genes:u:ube3a|UBE3A]]|0.415|
|[[:human genes:f:fnta|FNTA]]|0.405|
|[[:human genes:t:taf5l|TAF5L]]|0.402|
|[[:human genes:m:med23|MED23]]|0.402|
|[[:human genes:r:rnmt|RNMT]]|0.401|
|[[:human genes:a:aars|AARS]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 676/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|24/28|
|blood|25/28|
|bone|24/26|
|breast|30/33|
|central nervous system|53/56|
|cervix|4/4|
|colorectal|15/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|18/21|
|liver|18/20|
|lung|70/75|
|lymphocyte|15/16|
|ovary|24/26|
|pancreas|23/24|
|peripheral nervous system|11/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|20/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|27/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2088
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARIH1 Expression in NALM6 Cells: 7.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>