ARL1 [The Human Chemical-Genetic Interaction Map Project]

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======= ARL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARL1
  * **<color #00a2e8>Official Name</color>**: ADP ribosylation factor like GTPase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=400|400]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P40616|P40616]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603425|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus. {ECO:0000269|PubMed:9624189}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Arf|
|Miro|
|SRPRB|
|Ras|
|Gtr1 RagA|
|G-alpha|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|activation of phospholipase D activity|
|toxin metabolic process|
|protein localization to Golgi apparatus|
|enzyme activator activity|
|secondary metabolic process|
|positive regulation of phospholipase activity|
|regulation of phospholipase activity|
|positive regulation of lipase activity|
|trans-Golgi network membrane|
|retrograde transport, endosome to Golgi|
|regulation of lipase activity|
|Golgi organization|
|cytosolic transport|
|trans-Golgi network|
|endosomal transport|
|protein domain specific binding|
|GTPase activity|
|Golgi vesicle transport|
|GTP binding|
|endomembrane system organization|
|protein localization to organelle|
|positive regulation of hydrolase activity|
|Golgi apparatus|
|intracellular protein transport|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of molecular function|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-4.14|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-4.01|
|[[:results:exp169|BH1 1μM R04 exp169]]|-3.97|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-3.56|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-3.52|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-3.5|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-3.39|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-3.37|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-3.31|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-3.24|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-3.23|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-3.12|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-3.11|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-3.11|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-3.11|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-3.07|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-3.03|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-3.02|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-3.01|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.94|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-2.93|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-2.8|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-2.79|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-2.78|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-2.78|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.77|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.75|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-2.75|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-2.74|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-2.69|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-2.66|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.58|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.56|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-2.51|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-2.51|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-2.47|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-2.45|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-2.45|
|[[:results:exp11|CCCP 1μM R00 exp11]]|-2.44|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.41|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|-2.34|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-2.34|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-2.31|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-2.3|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-2.29|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-2.27|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2.26|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-2.26|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-2.26|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-2.18|
|[[:results:exp453|B02 10μM R08 exp453]]|-2.17|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-2.16|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.14|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-2.14|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|-2.14|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-2.13|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-2.12|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-2.12|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-2.11|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.09|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-2.09|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-2.07|
|[[:results:exp433|LJH685 50μM R08 exp433]]|-2.04|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-2.02|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-2.01|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-2|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-2|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-1.97|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-1.9|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-1.87|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-1.86|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.84|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|-1.82|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.81|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.81|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-1.8|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.8|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.79|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.76|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.75|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.73|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.64|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gpr107|GPR107]]|0.627|
|[[:human genes:z:zfat|ZFAT]]|0.615|
|[[:human genes:j:jtb|JTB]]|0.606|
|[[:human genes:c:cog5|COG5]]|0.536|
|[[:human genes:c:cog7|COG7]]|0.489|
|[[:human genes:m:mbtps1|MBTPS1]]|0.464|
|[[:human genes:w:wdr7|WDR7]]|0.455|
|[[:human genes:l:lsmd1|LSMD1]]|0.445|
|[[:human genes:s:sptlc1|SPTLC1]]|0.442|
|[[:human genes:a:atp6v0a2|ATP6V0A2]]|0.434|
|[[:human genes:c:chka|CHKA]]|0.431|
|[[:human genes:k:kiaa1432|KIAA1432]]|0.428|
|[[:human genes:c:c10orf76|C10orf76]]|0.425|
|[[:human genes:u:unc50|UNC50]]|0.416|
|[[:human genes:f:flvcr1|FLVCR1]]|0.402|
|[[:human genes:a:atp6v1g1|ATP6V1G1]]|0.402|
|[[:human genes:r:rgp1|RGP1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5446
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARL1 Expression in NALM6 Cells: 5.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>