ARL2 [The Human Chemical-Genetic Interaction Map Project]

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======= ARL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARL2
  * **<color #00a2e8>Official Name</color>**: ADP ribosylation factor like GTPase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=402|402]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P36404|P36404]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601175|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle. {ECO:0000269|PubMed:10831612, ECO:0000269|PubMed:16525022, ECO:0000269|PubMed:18234692, ECO:0000269|PubMed:18588884, ECO:0000269|PubMed:20740604}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ras|
|G-alpha|
|Gtr1 RagA|
|Arf|
|Miro|
|SRPRB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tubulin complex assembly|
|GTPase inhibitor activity|
|maintenance of protein location in nucleus|
|positive regulation of microtubule polymerization|
|positive regulation of microtubule polymerization or depolymerization|
|bicellular tight junction assembly|
|tight junction assembly|
|tight junction organization|
|maintenance of protein localization in organelle|
|apical junction assembly|
|negative regulation of GTPase activity|
|regulation of microtubule polymerization|
|lateral plasma membrane|
|GDP binding|
|maintenance of protein location in cell|
|mitochondrial intermembrane space|
|regulation of microtubule polymerization or depolymerization|
|centrosome cycle|
|microtubule organizing center organization|
|maintenance of location in cell|
|cell-cell junction assembly|
|maintenance of protein location|
|positive regulation of cell-substrate adhesion|
|positive regulation of protein polymerization|
|cell-cell junction organization|
|microtubule cytoskeleton|
|protein localization to nucleus|
|maintenance of location|
|cell junction assembly|
|regulation of insulin secretion|
|regulation of microtubule cytoskeleton organization|
|positive regulation of supramolecular fiber organization|
|cilium|
|regulation of peptide hormone secretion|
|regulation of cell-substrate adhesion|
|cell junction organization|
|positive regulation of cytoskeleton organization|
|regulation of microtubule-based process|
|regulation of protein polymerization|
|positive regulation of protein complex assembly|
|regulation of hormone secretion|
|GTPase activity|
|regulation of supramolecular fiber organization|
|mitochondrial matrix|
|GTP binding|
|positive regulation of cell adhesion|
|focal adhesion|
|regulation of protein complex assembly|
|negative regulation of hydrolase activity|
|regulation of protein secretion|
|microtubule cytoskeleton organization|
|regulation of GTPase activity|
|centrosome|
|regulation of peptide secretion|
|positive regulation of cellular component biogenesis|
|regulation of hormone levels|
|regulation of cytoskeleton organization|
|positive regulation of organelle organization|
|microtubule-based process|
|regulation of cell adhesion|
|regulation of protein transport|
|protein localization to organelle|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|negative regulation of catalytic activity|
|regulation of secretion|
|cellular protein-containing complex assembly|
|nucleolus|
|regulation of cellular component biogenesis|
|Golgi apparatus|
|cell cycle process|
|regulation of protein localization|
|cytoskeleton organization|
|negative regulation of molecular function|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|regulation of organelle organization|
|cell cycle|
|protein-containing complex assembly|
|cellular protein localization|
|cellular macromolecule localization|
|protein-containing complex subunit organization|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp453|B02 10μM R08 exp453]]|-2.52|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-2.36|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-2.3|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.98|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-1.98|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.523|
|[[:human genes:t:tbcd|TBCD]]|0.513|
|[[:human genes:v:vbp1|VBP1]]|0.408|
|[[:human genes:s:ska1|SKA1]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 736/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 527
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARL2 Expression in NALM6 Cells: 3.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>