ARL3 [The Human Chemical-Genetic Interaction Map Project]

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======= ARL3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARL3
  * **<color #00a2e8>Official Name</color>**: ADP ribosylation factor like GTPase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=403|403]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P36405|P36405]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARL3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARL3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604695|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase- activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins such as NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium. Does not act as an allosteric activator of the cholera toxin catalytic subunit. {ECO:0000269|PubMed:16525022, ECO:0000269|PubMed:18588884, ECO:0000269|PubMed:22085962}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Miro|
|Arf|
|SRPRB|
|Ras|
|Gtr1 RagA|
|G-alpha|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization to ciliary membrane|
|GTPase activating protein binding|
|spindle microtubule|
|photoreceptor connecting cilium|
|photoreceptor cell development|
|protein localization to cilium|
|intraciliary transport|
|cytoplasmic microtubule|
|photoreceptor cell differentiation|
|Golgi to plasma membrane transport|
|microtubule-based protein transport|
|protein transport along microtubule|
|mitotic cytokinesis|
|smoothened signaling pathway|
|GDP binding|
|vesicle-mediated transport to the plasma membrane|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|post-Golgi vesicle-mediated transport|
|microtubule cytoskeleton|
|transport along microtubule|
|midbody|
|cytoskeleton-dependent intracellular transport|
|microtubule-based transport|
|cilium|
|magnesium ion binding|
|protein localization to cell periphery|
|microtubule binding|
|protein-containing complex localization|
|kidney development|
|microtubule-based movement|
|renal system development|
|urogenital system development|
|small GTPase mediated signal transduction|
|GTPase activity|
|cilium assembly|
|cilium organization|
|Golgi vesicle transport|
|GTP binding|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|protein localization to membrane|
|centrosome|
|cell division|
|mitotic cell cycle process|
|Golgi membrane|
|microtubule-based process|
|mitotic cell cycle|
|protein localization to organelle|
|organelle assembly|
|neuron development|
|Golgi apparatus|
|intracellular protein transport|
|cell cycle process|
|neuron differentiation|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|cell cycle|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|cell development|
|intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp112|S-DABN 8μM R03 exp112]]|-1.93|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-1.71|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.7|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17987
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARL3 Expression in NALM6 Cells: 3.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>