ARNTL [The Human Chemical-Genetic Interaction Map Project]

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======= ARNTL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARNTL
  * **<color #00a2e8>Official Name</color>**: aryl hydrocarbon receptor nuclear translocator like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=406|406]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00327|O00327]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARNTL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARNTL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PAS|
|PAS 3|
|HLH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|oxidative stress-induced premature senescence|
|positive regulation of skeletal muscle cell differentiation|
|negative regulation of glucocorticoid receptor signaling pathway|
|maternal process involved in parturition|
|regulation of glucocorticoid receptor signaling pathway|
|stress-induced premature senescence|
|regulation of type B pancreatic cell development|
|aryl hydrocarbon receptor binding|
|chromatoid body|
|response to redox state|
|parturition|
|positive regulation of circadian rhythm|
|regulation of skeletal muscle cell differentiation|
|positive regulation of skeletal muscle tissue development|
|bHLH transcription factor binding|
|regulation of hair cycle|
|cellular senescence|
|negative regulation of intracellular steroid hormone receptor signaling pathway|
|repressing transcription factor binding|
|Hsp90 protein binding|
|regulation of cellular senescence|
|positive regulation of protein acetylation|
|negative regulation of fat cell differentiation|
|negative regulation of cold-induced thermogenesis|
|regulation of cell aging|
|regulation of skeletal muscle tissue development|
|negative regulation of TOR signaling|
|E-box binding|
|circadian regulation of gene expression|
|cell aging|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle organ development|
|positive regulation of muscle tissue development|
|regulation of protein acetylation|
|transcription regulatory region sequence-specific DNA binding|
|regulation of intracellular steroid hormone receptor signaling pathway|
|protein import into nucleus|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|PML body|
|regulation of TOR signaling|
|import into nucleus|
|regulation of circadian rhythm|
|regulation of fat cell differentiation|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|circadian rhythm|
|protein import|
|regulation of epithelial cell differentiation|
|regulation of cold-induced thermogenesis|
|positive regulation of canonical Wnt signaling pathway|
|protein localization to nucleus|
|positive regulation of Wnt signaling pathway|
|regulation of insulin secretion|
|transcription factor complex|
|regulation of peptide hormone secretion|
|multi-multicellular organism process|
|cellular response to oxidative stress|
|nucleocytoplasmic transport|
|nuclear transport|
|regulation of hormone secretion|
|rhythmic process|
|aging|
|regulation of canonical Wnt signaling pathway|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|regulation of Wnt signaling pathway|
|regulation of protein catabolic process|
|response to oxidative stress|
|sequence-specific DNA binding|
|establishment of protein localization to organelle|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of protein secretion|
|protein heterodimerization activity|
|regulation of peptide secretion|
|negative regulation of intracellular signal transduction|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|regulation of hormone levels|
|spermatogenesis|
|modification-dependent macromolecule catabolic process|
|male gamete generation|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|intracellular membrane-bounded organelle|
|gamete generation|
|regulation of protein transport|
|negative regulation of cell differentiation|
|regulation of cellular response to stress|
|protein localization to organelle|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|regulation of neurogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|cellular macromolecule catabolic process|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|multi-organism reproductive process|
|regulation of catabolic process|
|intracellular protein transport|
|regulation of protein localization|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|proteolysis|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|generation of neurons|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13168
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARNTL Expression in NALM6 Cells: 4.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>