ARR3 [The Human Chemical-Genetic Interaction Map Project]

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======= ARR3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ARR3
  * **<color #00a2e8>Official Name</color>**: arrestin 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=407|407]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P36575|P36575]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ARR3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ARR3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/301770|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a non-visual arrestin which binds to agonist-activated, phosphorylated G protein-coupled receptors. This binding uncouples the receptor from the heterotrimeric G protein, resulting in termination of the G protein-coupled receptor signaling. The encoded protein also is a part of the centrosome, interacting with gamma-tubulin to help regulate proper centrosome function. [provided by RefSeq, May 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Arrestin N|
|Arrestin C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|opsin binding|
|G protein-coupled receptor internalization|
|negative adaptation of signaling pathway|
|desensitization of G protein-coupled receptor signaling pathway|
|adaptation of signaling pathway|
|phosphoprotein binding|
|negative regulation of G protein-coupled receptor signaling pathway|
|photoreceptor inner segment|
|photoreceptor outer segment|
|receptor internalization|
|G protein-coupled receptor binding|
|receptor metabolic process|
|regulation of G protein-coupled receptor signaling pathway|
|visual perception|
|sensory perception of light stimulus|
|receptor-mediated endocytosis|
|synapse|
|endocytosis|
|import into cell|
|sensory perception|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|nervous system process|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-1.74|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|1.73|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.78|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|1.79|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.81|
|[[:results:exp358|FK-506 5μM R07 exp358]]|1.84|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9598
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ARR3 Expression in NALM6 Cells: -0.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>