ART4 [The Human Chemical-Genetic Interaction Map Project]

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======= ART4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ART4
  * **<color #00a2e8>Official Name</color>**: ADP-ribosyltransferase 4 (Dombrock blood group)
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=420|420]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q93070|Q93070]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ART4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ART4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/110600|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ART|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|peptidyl-arginine ADP-ribosylation|
|NAD(P)+-protein-arginine ADP-ribosyltransferase activity|
|arginine metabolic process|
|NAD+ ADP-ribosyltransferase activity|
|peptidyl-arginine modification|
|protein ADP-ribosylation|
|glutamine family amino acid metabolic process|
|anchored component of membrane|
|alpha-amino acid metabolic process|
|cellular amino acid metabolic process|
|peptidyl-amino acid modification|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|small molecule metabolic process|
|extracellular region|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|1.78|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|2.04|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10822
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ART4 Expression in NALM6 Cells: 3.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>