ART5 [The Human Chemical-Genetic Interaction Map Project]

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======= ART5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ART5
  * **<color #00a2e8>Official Name</color>**: ADP-ribosyltransferase 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=116969|116969]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96L15|Q96L15]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ART5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ART5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610625|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ART|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|peptidyl-arginine ADP-ribosylation|
|NAD(P)+-protein-arginine ADP-ribosyltransferase activity|
|peptidyl-arginine modification|
|NAD+ ADP-ribosyltransferase activity|
|protein ADP-ribosylation|
|peptidyl-amino acid modification|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp219|A-395N 10μM R05 exp219]]|1.75|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|1.85|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.494|
|[[:human genes:a:aqr|AQR]]|0.479|
|[[:human genes:a:apc2|APC2]]|0.476|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.467|
|[[:human genes:p:psma6|PSMA6]]|0.459|
|[[:human genes:r:rpl35|RPL35]]|0.458|
|[[:human genes:r:rps2|RPS2]]|0.456|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.452|
|[[:human genes:p:psmd2|PSMD2]]|0.448|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.44|
|[[:human genes:c:ccna2|CCNA2]]|0.439|
|[[:human genes:p:psmb4|PSMB4]]|0.434|
|[[:human genes:c:chd4|CHD4]]|0.43|
|[[:human genes:c:ccdc116|CCDC116]]|0.43|
|[[:human genes:a:akt1s1|AKT1S1]]|0.429|
|[[:human genes:f:fam25b|FAM25B]]|0.428|
|[[:human genes:r:rpl6|RPL6]]|0.426|
|[[:human genes:t:timeless|TIMELESS]]|0.426|
|[[:human genes:u:ube2q2l|UBE2Q2L]]|0.425|
|[[:human genes:p:psmb2|PSMB2]]|0.424|
|[[:human genes:s:s1pr4|S1PR4]]|0.423|
|[[:human genes:s:scgb1c1|SCGB1C1]]|0.422|
|[[:human genes:r:rps7|RPS7]]|0.419|
|[[:human genes:r:rrp7a|RRP7A]]|0.418|
|[[:human genes:n:nop16|NOP16]]|0.416|
|[[:human genes:u:utp3|UTP3]]|0.415|
|[[:human genes:x:xylt2|XYLT2]]|0.409|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.403|
|[[:human genes:s:slc38a7|SLC38A7]]|0.403|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.403|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.402|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2233
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ART5 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>