ASGR1 [The Human Chemical-Genetic Interaction Map Project]

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======= ASGR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ASGR1
  * **<color #00a2e8>Official Name</color>**: asialoglycoprotein receptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=432|432]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P07306|P07306]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ASGR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ASGR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/108360|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lectin C|
|Lectin N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|asialoglycoprotein receptor activity|
|protein N-linked glycosylation via asparagine|
|peptidyl-asparagine modification|
|protein N-linked glycosylation|
|carbohydrate binding|
|receptor-mediated endocytosis|
|protein glycosylation|
|macromolecule glycosylation|
|cellular response to extracellular stimulus|
|glycosylation|
|glycoprotein biosynthetic process|
|cellular response to external stimulus|
|glycoprotein metabolic process|
|response to extracellular stimulus|
|endocytosis|
|carbohydrate derivative biosynthetic process|
|import into cell|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|protein homodimerization activity|
|peptidyl-amino acid modification|
|carbohydrate derivative metabolic process|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-2.17|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14315
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ASGR1 Expression in NALM6 Cells: 2.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>