ASIC1 [The Human Chemical-Genetic Interaction Map Project]

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======= ASIC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ASIC1
  * **<color #00a2e8>Official Name</color>**: acid sensing ion channel subunit 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=41|41]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P78348|P78348]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ASIC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ASIC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602866|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear. {ECO:0000269|PubMed:22760635}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ASC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|acid-sensing ion channel activity|
|sensory perception of sour taste|
|ligand-gated sodium channel activity|
|negative regulation of neurotransmitter secretion|
|negative regulation of neurotransmitter transport|
|cellular response to pH|
|response to acidic pH|
|behavioral fear response|
|behavioral defense response|
|response to amphetamine|
|protein homotrimerization|
|fear response|
|response to pH|
|response to amine|
|response to bronchodilator|
|protein trimerization|
|negative regulation of synaptic transmission|
|sensory perception of taste|
|multicellular organismal response to stress|
|associative learning|
|sodium ion transmembrane transport|
|regulation of neurotransmitter secretion|
|memory|
|regulation of neurotransmitter transport|
|learning|
|sodium ion transport|
|calcium ion transmembrane transport|
|negative regulation of secretion by cell|
|negative regulation of secretion|
|calcium ion transport|
|learning or memory|
|synapse|
|divalent metal ion transport|
|cognition|
|response to xenobiotic stimulus|
|divalent inorganic cation transport|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|protein homooligomerization|
|regulation of neurotransmitter levels|
|monovalent inorganic cation transport|
|regulation of membrane potential|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|negative regulation of transport|
|response to toxic substance|
|protein complex oligomerization|
|sensory perception of chemical stimulus|
|inorganic cation transmembrane transport|
|behavior|
|cation transmembrane transport|
|cell surface|
|metal ion transport|
|inorganic ion transmembrane transport|
|regulation of secretion by cell|
|regulation of secretion|
|cation transport|
|regulation of cellular localization|
|ion transmembrane transport|
|sensory perception|
|Golgi apparatus|
|response to organonitrogen compound|
|response to drug|
|response to nitrogen compound|
|response to abiotic stimulus|
|transmembrane transport|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|1.76|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6844
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ASIC1 Expression in NALM6 Cells: 3.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>