ASIC2 [The Human Chemical-Genetic Interaction Map Project]

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======= ASIC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ASIC2
  * **<color #00a2e8>Official Name</color>**: acid sensing ion channel subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=40|40]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16515|Q16515]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ASIC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ASIC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601784|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ASC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback|
|regulation of systemic arterial blood pressure by baroreceptor feedback|
|sensory perception of sour taste|
|ligand-gated sodium channel activity|
|nervous system process involved in regulation of systemic arterial blood pressure|
|response to acidic pH|
|detection of mechanical stimulus involved in sensory perception|
|response to pH|
|phototransduction|
|detection of mechanical stimulus|
|regulation of vasoconstriction|
|detection of light stimulus|
|protein localization to synapse|
|positive regulation of synapse assembly|
|sensory perception of taste|
|peripheral nervous system development|
|sodium ion transmembrane transport|
|regulation of systemic arterial blood pressure|
|regulation of synapse assembly|
|detection of external stimulus|
|detection of abiotic stimulus|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|sensory perception of sound|
|dendritic spine|
|sodium ion transport|
|sensory perception of mechanical stimulus|
|vascular process in circulatory system|
|regulation of blood pressure|
|response to mechanical stimulus|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|regulation of blood circulation|
|response to light stimulus|
|neuronal cell body|
|blood circulation|
|circulatory system process|
|monovalent inorganic cation transport|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|regulation of membrane potential|
|trans-synaptic signaling|
|response to radiation|
|synaptic signaling|
|regulation of ion transmembrane transport|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|positive regulation of nervous system development|
|sensory perception of chemical stimulus|
|detection of stimulus involved in sensory perception|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|regulation of system process|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|detection of stimulus|
|regulation of ion transport|
|cation transport|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of nervous system development|
|ion transmembrane transport|
|regulation of cellular component biogenesis|
|sensory perception|
|central nervous system development|
|negative regulation of cell death|
|cell-cell signaling|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|transmembrane transport|
|positive regulation of developmental process|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-2.04|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|1.81|
|[[:results:exp495|IWR1 50μM R08 exp495]]|2.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15586
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.35 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ASIC2 Expression in NALM6 Cells: -3.35'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>