ATG9B [The Human Chemical-Genetic Interaction Map Project]

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======= ATG9B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATG9B
  * **<color #00a2e8>Official Name</color>**: autophagy related 9B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=285973|285973]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q674R7|Q674R7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATG9B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATG9B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612205|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene functions in the regulation of autophagy, a lysosomal degradation pathway. This gene also functions as an antisense transcript in the posttranscriptional regulation of the endothelial nitric oxide synthase 3 gene, which has 3' overlap with this gene on the opposite strand. Mutations in this gene and disruption of the autophagy process have been associated with multiple cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|APG9|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|late nucleophagy|
|autophagy of nucleus|
|protein localization to phagophore assembly site|
|phagophore assembly site|
|autophagosome membrane|
|mitochondrion disassembly|
|autophagy of mitochondrion|
|autophagosome assembly|
|organelle disassembly|
|autophagosome organization|
|autophagosome|
|vacuole organization|
|macroautophagy|
|cytoplasmic vesicle|
|autophagy|
|process utilizing autophagic mechanism|
|cellular component disassembly|
|mitochondrion organization|
|organelle assembly|
|cellular protein localization|
|cellular macromolecule localization|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18189
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATG9B Expression in NALM6 Cells: -0.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>