ATP11C [The Human Chemical-Genetic Interaction Map Project]

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======= ATP11C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP11C
  * **<color #00a2e8>Official Name</color>**: ATPase phospholipid transporting 11C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=286410|286410]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NB49|Q8NB49]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP11C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP11C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300516|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|E1-E2 ATPase|
|HAD|
|Hydrolase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pre-B cell differentiation|
|immature B cell differentiation|
|positive regulation of B cell differentiation|
|ATPase-coupled intramembrane lipid transporter activity|
|regulation of B cell differentiation|
|phospholipid translocation|
|lipid translocation|
|regulation of membrane lipid distribution|
|phospholipid transport|
|positive regulation of lymphocyte differentiation|
|B cell differentiation|
|recycling endosome|
|organophosphate ester transport|
|positive regulation of leukocyte differentiation|
|B cell activation|
|positive regulation of B cell activation|
|regulation of lymphocyte differentiation|
|trans-Golgi network|
|positive regulation of hemopoiesis|
|regulation of B cell activation|
|magnesium ion binding|
|lymphocyte differentiation|
|regulation of leukocyte differentiation|
|lipid transport|
|lysosomal membrane|
|lipid localization|
|leukocyte differentiation|
|positive regulation of lymphocyte activation|
|lymphocyte activation|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|regulation of hemopoiesis|
|organic anion transport|
|regulation of lymphocyte activation|
|hemopoiesis|
|anion transport|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|regulation of cell activation|
|immune system development|
|membrane organization|
|leukocyte activation|
|endoplasmic reticulum membrane|
|ion transmembrane transport|
|positive regulation of cell differentiation|
|endoplasmic reticulum|
|cell activation|
|positive regulation of immune system process|
|transmembrane transport|
|positive regulation of developmental process|
|ion transport|
|ATP binding|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.76|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18690
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP11C Expression in NALM6 Cells: 6.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>