ATP13A1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= ATP13A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP13A1
  * **<color #00a2e8>Official Name</color>**: ATPase 13A1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57130|57130]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HD20|Q9HD20]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP13A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP13A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619118|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis. {ECO:0000269|PubMed:24392018}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|E1-E2 ATPase|
|HAD|
|Hydrolase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|manganese transmembrane transporter activity, phosphorylative mechanism|
|manganese ion transmembrane transport|
|manganese ion transport|
|transition metal ion transport|
|ATPase activity|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|molecular function|
|ion homeostasis|
|cation transport|
|cellular homeostasis|
|endoplasmic reticulum membrane|
|ion transmembrane transport|
|chemical homeostasis|
|transmembrane transport|
|ion transport|
|ATP binding|
|homeostatic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-3.03|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-2.38|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.27|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-2.12|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.03|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-2|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.96|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|-1.82|
|[[:results:exp134|MS023 2μM R03 exp134]]|-1.8|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.77|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-1.76|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-1.73|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.72|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:b:bcl2l1|BCL2L1]]|0.636|
|[[:human genes:z:zfand5|ZFAND5]]|0.612|
|[[:human genes:s:smg7|SMG7]]|0.57|
|[[:human genes:s:smg1|SMG1]]|0.547|
|[[:human genes:p:psmd1|PSMD1]]|0.532|
|[[:human genes:p:psmc2|PSMC2]]|0.515|
|[[:human genes:k:kpnb1|KPNB1]]|0.502|
|[[:human genes:p:psmb2|PSMB2]]|0.5|
|[[:human genes:p:psma6|PSMA6]]|0.499|
|[[:human genes:s:smg5|SMG5]]|0.494|
|[[:human genes:e:eif3l|EIF3L]]|0.488|
|[[:human genes:d:ddtl|DDTL]]|0.486|
|[[:human genes:n:ndc1|NDC1]]|0.484|
|[[:human genes:p:psmc1|PSMC1]]|0.483|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.483|
|[[:human genes:p:psma7|PSMA7]]|0.481|
|[[:human genes:w:wdr43|WDR43]]|0.475|
|[[:human genes:p:psmd11|PSMD11]]|0.471|
|[[:human genes:p:pan3|PAN3]]|0.466|
|[[:human genes:p:plcg2|PLCG2]]|0.466|
|[[:human genes:p:psmb4|PSMB4]]|0.465|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.46|
|[[:human genes:t:tceb3c|TCEB3C]]|0.46|
|[[:human genes:e:eif3k|EIF3K]]|0.458|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.456|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.455|
|[[:human genes:a:aaas|AAAS]]|0.454|
|[[:human genes:c:cbwd3|CBWD3]]|0.454|
|[[:human genes:s:ssh2|SSH2]]|0.453|
|[[:human genes:u:upf1|UPF1]]|0.451|
|[[:human genes:d:disp2|DISP2]]|0.45|
|[[:human genes:p:pan2|PAN2]]|0.449|
|[[:human genes:n:nup54|NUP54]]|0.448|
|[[:human genes:c:cbwd5|CBWD5]]|0.447|
|[[:human genes:c:chd4|CHD4]]|0.446|
|[[:human genes:c:ctr9|CTR9]]|0.445|
|[[:human genes:s:sel1l|SEL1L]]|0.444|
|[[:human genes:s:snrpa1|SNRPA1]]|0.444|
|[[:human genes:n:nfe2l1|NFE2L1]]|0.436|
|[[:human genes:l:lrr1|LRR1]]|0.434|
|[[:human genes:p:psmd2|PSMD2]]|0.433|
|[[:human genes:c:cdca3|CDCA3]]|0.432|
|[[:human genes:m:mdm2|MDM2]]|0.431|
|[[:human genes:n:nup188|NUP188]]|0.43|
|[[:human genes:p:pole|POLE]]|0.429|
|[[:human genes:p:psma1|PSMA1]]|0.426|
|[[:human genes:d:dtl|DTL]]|0.425|
|[[:human genes:m:mt1e|MT1E]]|0.423|
|[[:human genes:r:rpl35|RPL35]]|0.422|
|[[:human genes:p:psmb1|PSMB1]]|0.42|
|[[:human genes:p:polr2j3|POLR2J3]]|0.42|
|[[:human genes:c:clptm1|CLPTM1]]|0.419|
|[[:human genes:t:traip|TRAIP]]|0.419|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.416|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.416|
|[[:human genes:p:psmc6|PSMC6]]|0.416|
|[[:human genes:c:ccdc116|CCDC116]]|0.416|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.416|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.415|
|[[:human genes:p:pwp2|PWP2]]|0.415|
|[[:human genes:l:lad1|LAD1]]|0.415|
|[[:human genes:n:nup85|NUP85]]|0.415|
|[[:human genes:p:psmd13|PSMD13]]|0.414|
|[[:human genes:s:sec13|SEC13]]|0.414|
|[[:human genes:r:rrn3|RRN3]]|0.414|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.414|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.414|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.413|
|[[:human genes:p:psmd6|PSMD6]]|0.411|
|[[:human genes:a:akap1|AKAP1]]|0.41|
|[[:human genes:c:cbwd6|CBWD6]]|0.41|
|[[:human genes:i:igfn1|IGFN1]]|0.408|
|[[:human genes:c:clasp1|CLASP1]]|0.408|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.408|
|[[:human genes:c:cdc45|CDC45]]|0.407|
|[[:human genes:c:ccna2|CCNA2]]|0.407|
|[[:human genes:n:nup160|NUP160]]|0.407|
|[[:human genes:r:rps3|RPS3]]|0.404|
|[[:human genes:p:psmc3|PSMC3]]|0.404|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.404|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.404|
|[[:human genes:r:rrp7a|RRP7A]]|0.402|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.402|
|[[:human genes:x:xiap|XIAP]]|0.4|
|[[:human genes:a:ahctf1|AHCTF1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1289
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP13A1 Expression in NALM6 Cells: 7.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>