ATP1B1 [The Human Chemical-Genetic Interaction Map Project]

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======= ATP1B1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP1B1
  * **<color #00a2e8>Official Name</color>**: ATPase Na+/K+ transporting subunit beta 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=481|481]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P05026|P05026]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP1B1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP1B1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/182330|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known. [provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. {ECO:0000269|PubMed:19694409}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Na K-ATPase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein transport into plasma membrane raft|
|positive regulation of calcium:sodium antiporter activity|
|regulation of calcium:sodium antiporter activity|
|positive regulation of sodium ion export across plasma membrane|
|regulation of sodium ion export across plasma membrane|
|protein localization to plasma membrane raft|
|protein transport into membrane raft|
|positive regulation of potassium ion import across plasma membrane|
|regulation of potassium ion import|
|protein localization to membrane raft|
|protein transport within lipid bilayer|
|sodium ion binding|
|sodium:potassium-exchanging ATPase activity|
|potassium ion binding|
|sodium:potassium-exchanging ATPase complex|
|cellular potassium ion homeostasis|
|relaxation of cardiac muscle|
|sodium ion export across plasma membrane|
|establishment or maintenance of transmembrane electrochemical gradient|
|cell communication by electrical coupling involved in cardiac conduction|
|MHC class II protein complex binding|
|positive regulation of sodium ion transmembrane transporter activity|
|cellular sodium ion homeostasis|
|membrane repolarization during cardiac muscle cell action potential|
|membrane repolarization during action potential|
|cell communication by electrical coupling|
|cardiac muscle cell membrane repolarization|
|positive regulation of sodium ion transmembrane transport|
|relaxation of muscle|
|membrane repolarization|
|positive regulation of potassium ion transmembrane transporter activity|
|ATPase activator activity|
|regulation of cardiac muscle contraction by calcium ion signaling|
|potassium ion homeostasis|
|sodium ion homeostasis|
|positive regulation of sodium ion transport|
|positive regulation of potassium ion transmembrane transport|
|positive regulation of calcium ion transmembrane transporter activity|
|export across plasma membrane|
|potassium ion import across plasma membrane|
|cell communication involved in cardiac conduction|
|positive regulation of potassium ion transport|
|intercalated disc|
|cardiac muscle cell action potential|
|regulation of sodium ion transmembrane transporter activity|
|positive regulation of ATPase activity|
|extracellular vesicle|
|regulation of potassium ion transmembrane transporter activity|
|drug binding|
|regulation of sodium ion transmembrane transport|
|regulation of cardiac conduction|
|positive regulation of calcium ion transmembrane transport|
|caveola|
|inorganic ion import across plasma membrane|
|inorganic cation import across plasma membrane|
|regulation of cardiac muscle contraction|
|cardiac muscle contraction|
|regulation of potassium ion transmembrane transport|
|ATPase binding|
|regulation of ATPase activity|
|localization within membrane|
|regulation of sodium ion transport|
|heart contraction|
|regulation of calcium ion transmembrane transporter activity|
|sodium ion transmembrane transport|
|regulation of striated muscle contraction|
|cardiac conduction|
|action potential|
|regulation of potassium ion transport|
|import across plasma membrane|
|sarcolemma|
|heart process|
|positive regulation of ion transmembrane transporter activity|
|cellular monovalent inorganic cation homeostasis|
|striated muscle contraction|
|positive regulation of transporter activity|
|positive regulation of calcium ion transport|
|multicellular organismal signaling|
|monovalent inorganic cation homeostasis|
|positive regulation of cation transmembrane transport|
|calcium-mediated signaling|
|regulation of calcium ion transmembrane transport|
|sodium ion transport|
|positive regulation of ion transmembrane transport|
|potassium ion transmembrane transport|
|regulation of muscle contraction|
|potassium ion transport|
|protein stabilization|
|protein localization to plasma membrane|
|protein C-terminus binding|
|basolateral plasma membrane|
|positive regulation of transmembrane transport|
|ATP metabolic process|
|protein localization to cell periphery|
|ATPase activity|
|regulation of muscle system process|
|regulation of heart contraction|
|regulation of calcium ion transport|
|muscle contraction|
|regulation of ion transmembrane transporter activity|
|establishment of protein localization to membrane|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|regulation of protein stability|
|regulation of blood circulation|
|muscle system process|
|apical plasma membrane|
|regulation of cation transmembrane transport|
|second-messenger-mediated signaling|
|response to hypoxia|
|response to decreased oxygen levels|
|leukocyte migration|
|response to oxygen levels|
|regulation of metal ion transport|
|blood circulation|
|circulatory system process|
|monovalent inorganic cation transport|
|regulation of membrane potential|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|protein kinase binding|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|protein localization to membrane|
|divalent inorganic cation homeostasis|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|regulation of system process|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|import into cell|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|positive regulation of hydrolase activity|
|ion homeostasis|
|cation transport|
|membrane organization|
|cellular homeostasis|
|cell adhesion|
|biological adhesion|
|ion transmembrane transport|
|cell migration|
|positive regulation of transport|
|intracellular protein transport|
|export from cell|
|cell motility|
|localization of cell|
|chemical homeostasis|
|response to abiotic stimulus|
|regulation of hydrolase activity|
|transmembrane transport|
|locomotion|
|ion transport|
|positive regulation of catalytic activity|
|ATP binding|
|protein transport|
|intracellular transport|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|homeostatic process|
|intracellular signal transduction|
|positive regulation of molecular function|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16598
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP1B1 Expression in NALM6 Cells: 1.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>