ATP5E [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= ATP5E =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP5F1E
  * **<color #00a2e8>Official Name</color>**: ATP synthase F1 subunit epsilon
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=514|514]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P56381|P56381]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP5E&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP5E|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606153|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the epsilon subunit of the catalytic core. Two pseudogenes of this gene are located on chromosomes 4 and 13. Read-through transcripts that include exons from this gene are expressed from the upstream gene SLMO2.[provided by RefSeq, Mar 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ATP-synt Eps|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)|
|mitochondrial proton-transporting ATP synthase complex|
|proton-transporting ATP synthase activity, rotational mechanism|
|mitochondrial ATP synthesis coupled proton transport|
|energy coupled proton transport, down electrochemical gradient|
|ATP synthesis coupled proton transport|
|cristae formation|
|ATP biosynthetic process|
|inner mitochondrial membrane organization|
|purine ribonucleoside triphosphate biosynthetic process|
|purine nucleoside triphosphate biosynthetic process|
|ribonucleoside triphosphate biosynthetic process|
|purine ribonucleoside triphosphate metabolic process|
|transmembrane transporter activity|
|nucleoside triphosphate biosynthetic process|
|ribonucleoside triphosphate metabolic process|
|purine nucleoside triphosphate metabolic process|
|mitochondrial transmembrane transport|
|nucleoside triphosphate metabolic process|
|oxidative phosphorylation|
|mitochondrial membrane organization|
|proton transmembrane transport|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|ATP metabolic process|
|mitochondrial transport|
|ATPase activity|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|mitochondrial matrix|
|mitochondrial inner membrane|
|monovalent inorganic cation transport|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|drug metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|carbohydrate derivative biosynthetic process|
|inorganic ion transmembrane transport|
|cation transport|
|membrane organization|
|organophosphate metabolic process|
|ion transmembrane transport|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|transmembrane transport|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|ion transport|
|organonitrogen compound biosynthetic process|
|intracellular transport|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.26|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.7|
|[[:results:exp519|RS-1 10μM R08 exp519]]|1.73|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.75|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.84|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.84|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|1.86|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.87|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.88|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.88|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|2.03|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.07|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.14|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.27|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.36|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.4|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.62|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.71|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atp5b|ATP5B]]|0.602|
|[[:human genes:a:atp5c1|ATP5C1]]|0.6|
|[[:human genes:a:atp5o|ATP5O]]|0.578|
|[[:human genes:a:atp5d|ATP5D]]|0.576|
|[[:human genes:a:atp5a1|ATP5A1]]|0.562|
|[[:human genes:a:atp5l|ATP5L]]|0.495|
|[[:human genes:b:bcs1l|BCS1L]]|0.488|
|[[:human genes:a:atp5j2|ATP5J2]]|0.484|
|[[:human genes:a:atp5h|ATP5H]]|0.481|
|[[:human genes:n:ndufa1|NDUFA1]]|0.481|
|[[:human genes:a:atp5f1|ATP5F1]]|0.476|
|[[:human genes:m:mrpl21|MRPL21]]|0.447|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.439|
|[[:human genes:m:mrp63|MRP63]]|0.438|
|[[:human genes:g:gatc|GATC]]|0.434|
|[[:human genes:p:pars2|PARS2]]|0.429|
|[[:human genes:a:atp5j|ATP5J]]|0.428|
|[[:human genes:g:gfm1|GFM1]]|0.427|
|[[:human genes:t:tmem242|TMEM242]]|0.424|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.423|
|[[:human genes:r:rpusd4|RPUSD4]]|0.423|
|[[:human genes:n:ndufc2|NDUFC2]]|0.423|
|[[:human genes:s:slc25a3|SLC25A3]]|0.421|
|[[:human genes:n:ndufb5|NDUFB5]]|0.421|
|[[:human genes:c:cox16|COX16]]|0.419|
|[[:human genes:m:mars2|MARS2]]|0.418|
|[[:human genes:n:ndufa3|NDUFA3]]|0.417|
|[[:human genes:s:sco2|SCO2]]|0.416|
|[[:human genes:m:mrps23|MRPS23]]|0.414|
|[[:human genes:n:ndufa2|NDUFA2]]|0.412|
|[[:human genes:n:ndufb11|NDUFB11]]|0.411|
|[[:human genes:c:c17orf89|C17orf89]]|0.411|
|[[:human genes:y:yars2|YARS2]]|0.411|
|[[:human genes:d:dap3|DAP3]]|0.411|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.411|
|[[:human genes:d:dars2|DARS2]]|0.403|
|[[:human genes:l:lars2|LARS2]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 163/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|9/28|
|blood|8/28|
|bone|4/26|
|breast|13/33|
|central nervous system|10/56|
|cervix|2/4|
|colorectal|5/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|3/21|
|liver|7/20|
|lung|19/75|
|lymphocyte|2/16|
|ovary|2/26|
|pancreas|2/24|
|peripheral nervous system|5/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|4/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|5/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1458
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP5E Expression in NALM6 Cells: 6.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>