ATP5J [The Human Chemical-Genetic Interaction Map Project]

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======= ATP5J =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP5PF
  * **<color #00a2e8>Official Name</color>**: ATP synthase peripheral stalk subunit F6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=522|522]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P18859|P18859]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP5J&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP5J|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603152|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ATP-synt F6|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of prostaglandin secretion|
|negative regulation of arachidonic acid secretion|
|negative regulation of icosanoid secretion|
|negative regulation of fatty acid transport|
|regulation of arachidonic acid secretion|
|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)|
|regulation of prostaglandin secretion|
|proton transmembrane transporter activity|
|mitochondrial proton-transporting ATP synthase complex|
|regulation of icosanoid secretion|
|negative regulation of organic acid transport|
|mitochondrial ATP synthesis coupled proton transport|
|response to muscle activity|
|positive regulation of heart rate|
|energy coupled proton transport, down electrochemical gradient|
|ATP synthesis coupled proton transport|
|negative regulation of lipid transport|
|regulation of fatty acid transport|
|negative regulation of anion transport|
|cristae formation|
|ATP biosynthetic process|
|positive regulation of blood pressure|
|positive regulation of heart contraction|
|negative regulation of lipid localization|
|substantia nigra development|
|inner mitochondrial membrane organization|
|purine ribonucleoside triphosphate biosynthetic process|
|purine nucleoside triphosphate biosynthetic process|
|ribonucleoside triphosphate biosynthetic process|
|regulation of organic acid transport|
|purine ribonucleoside triphosphate metabolic process|
|neural nucleus development|
|transmembrane transporter activity|
|nucleoside triphosphate biosynthetic process|
|response to activity|
|ribonucleoside triphosphate metabolic process|
|purine nucleoside triphosphate metabolic process|
|positive regulation of blood circulation|
|midbrain development|
|mitochondrial transmembrane transport|
|nucleoside triphosphate metabolic process|
|regulation of anion transport|
|regulation of heart rate|
|regulation of lipid transport|
|oxidative phosphorylation|
|mitochondrial membrane organization|
|regulation of lipid localization|
|proton transmembrane transport|
|negative regulation of ion transport|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|regulation of blood pressure|
|ATP metabolic process|
|mitochondrial transport|
|negative regulation of secretion|
|ATPase activity|
|regulation of heart contraction|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|protein-containing complex binding|
|regulation of blood circulation|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|blood circulation|
|mitochondrial inner membrane|
|circulatory system process|
|monovalent inorganic cation transport|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|negative regulation of transport|
|drug metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|inorganic cation transmembrane transport|
|regulation of system process|
|cation transmembrane transport|
|cell surface|
|carbohydrate derivative biosynthetic process|
|inorganic ion transmembrane transport|
|regulation of ion transport|
|brain development|
|head development|
|regulation of secretion|
|cation transport|
|membrane organization|
|organophosphate metabolic process|
|ion transmembrane transport|
|central nervous system development|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|transmembrane transport|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|ion transport|
|organonitrogen compound biosynthetic process|
|intracellular transport|
|extracellular space|
|cellular nitrogen compound biosynthetic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|establishment of localization in cell|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-2.36|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.13|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-2.03|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|-2.03|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|-1.97|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-1.81|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|-1.76|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|-1.74|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|-1.73|
|[[:results:exp149|SB203580 25μM R03 exp149]]|-1.73|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.79|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|1.79|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.82|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.9|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.94|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.94|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.98|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.03|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.1|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.13|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.19|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.27|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.28|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.37|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.47|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.96|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|3.02|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|3.14|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|3.53|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atp5b|ATP5B]]|0.628|
|[[:human genes:g:gfpt1|GFPT1]]|0.625|
|[[:human genes:t:thg1l|THG1L]]|0.613|
|[[:human genes:g:gmppb|GMPPB]]|0.606|
|[[:human genes:a:atp5o|ATP5O]]|0.589|
|[[:human genes:u:uap1|UAP1]]|0.588|
|[[:human genes:a:alg1|ALG1]]|0.583|
|[[:human genes:d:dpagt1|DPAGT1]]|0.576|
|[[:human genes:r:rnmt|RNMT]]|0.576|
|[[:human genes:h:hccs|HCCS]]|0.573|
|[[:human genes:h:hspd1|HSPD1]]|0.573|
|[[:human genes:p:pmm2|PMM2]]|0.571|
|[[:human genes:a:atp5a1|ATP5A1]]|0.571|
|[[:human genes:c:cycs|CYCS]]|0.567|
|[[:human genes:t:triap1|TRIAP1]]|0.565|
|[[:human genes:a:atp5i|ATP5I]]|0.559|
|[[:human genes:e:eny2|ENY2]]|0.556|
|[[:human genes:a:atp5d|ATP5D]]|0.555|
|[[:human genes:r:rptor|RPTOR]]|0.553|
|[[:human genes:u:ube2g2|UBE2G2]]|0.552|
|[[:human genes:d:dohh|DOHH]]|0.552|
|[[:human genes:e:exoc4|EXOC4]]|0.544|
|[[:human genes:a:atxn10|ATXN10]]|0.535|
|[[:human genes:a:alg2|ALG2]]|0.535|
|[[:human genes:c:casp9|CASP9]]|0.533|
|[[:human genes:a:alg13|ALG13]]|0.532|
|[[:human genes:s:slc25a26|SLC25A26]]|0.531|
|[[:human genes:a:atp5c1|ATP5C1]]|0.53|
|[[:human genes:d:dars2|DARS2]]|0.525|
|[[:human genes:a:alg5|ALG5]]|0.522|
|[[:human genes:a:adsl|ADSL]]|0.519|
|[[:human genes:b:bcs1l|BCS1L]]|0.515|
|[[:human genes:d:diablo|DIABLO]]|0.515|
|[[:human genes:r:rtcb|RTCB]]|0.512|
|[[:human genes:p:plaa|PLAA]]|0.51|
|[[:human genes:l:lsm10|LSM10]]|0.509|
|[[:human genes:p:ppa2|PPA2]]|0.508|
|[[:human genes:f:faf2|FAF2]]|0.507|
|[[:human genes:m:mrps14|MRPS14]]|0.506|
|[[:human genes:e:elac2|ELAC2]]|0.504|
|[[:human genes:d:dolk|DOLK]]|0.501|
|[[:human genes:a:atp5f1|ATP5F1]]|0.499|
|[[:human genes:r:rpp21|RPP21]]|0.493|
|[[:human genes:t:tufm|TUFM]]|0.492|
|[[:human genes:a:apaf1|APAF1]]|0.486|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.485|
|[[:human genes:m:mrp63|MRP63]]|0.485|
|[[:human genes:u:uba3|UBA3]]|0.484|
|[[:human genes:v:vezt|VEZT]]|0.481|
|[[:human genes:m:mbtps2|MBTPS2]]|0.478|
|[[:human genes:n:nae1|NAE1]]|0.478|
|[[:human genes:l:lsm11|LSM11]]|0.477|
|[[:human genes:c:cox16|COX16]]|0.475|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.475|
|[[:human genes:f:fh|FH]]|0.475|
|[[:human genes:u:uhrf1|UHRF1]]|0.474|
|[[:human genes:m:mtor|MTOR]]|0.474|
|[[:human genes:t:tmem242|TMEM242]]|0.474|
|[[:human genes:c:csnk2b|CSNK2B]]|0.474|
|[[:human genes:o:opa1|OPA1]]|0.473|
|[[:human genes:d:dhps|DHPS]]|0.473|
|[[:human genes:s:ssb|SSB]]|0.47|
|[[:human genes:g:gnb1l|GNB1L]]|0.469|
|[[:human genes:m:med16|MED16]]|0.468|
|[[:human genes:b:bap1|BAP1]]|0.467|
|[[:human genes:t:thoc6|THOC6]]|0.467|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.466|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.465|
|[[:human genes:c:ccdc101|CCDC101]]|0.465|
|[[:human genes:s:slc25a19|SLC25A19]]|0.465|
|[[:human genes:k:kdsr|KDSR]]|0.465|
|[[:human genes:r:rpusd4|RPUSD4]]|0.464|
|[[:human genes:a:atp5l|ATP5L]]|0.461|
|[[:human genes:p:polr3h|POLR3H]]|0.461|
|[[:human genes:c:cbfb|CBFB]]|0.459|
|[[:human genes:b:bak1|BAK1]]|0.459|
|[[:human genes:m:mrpl21|MRPL21]]|0.459|
|[[:human genes:d:dhrsx|DHRSX]]|0.458|
|[[:human genes:n:nupl2|NUPL2]]|0.457|
|[[:human genes:a:aars|AARS]]|0.457|
|[[:human genes:s:srp14|SRP14]]|0.456|
|[[:human genes:t:tmed10|TMED10]]|0.455|
|[[:human genes:m:mrps33|MRPS33]]|0.455|
|[[:human genes:a:atp5h|ATP5H]]|0.453|
|[[:human genes:t:tsen54|TSEN54]]|0.452|
|[[:human genes:h:hars|HARS]]|0.451|
|[[:human genes:z:zbtb11|ZBTB11]]|0.451|
|[[:human genes:y:yars2|YARS2]]|0.45|
|[[:human genes:n:nars|NARS]]|0.449|
|[[:human genes:y:yars|YARS]]|0.449|
|[[:human genes:m:meaf6|MEAF6]]|0.449|
|[[:human genes:d:dnajc3|DNAJC3]]|0.449|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.446|
|[[:human genes:t:tamm41|TAMM41]]|0.446|
|[[:human genes:m:mapk14|MAPK14]]|0.446|
|[[:human genes:c:crls1|CRLS1]]|0.445|
|[[:human genes:m:mrps16|MRPS16]]|0.445|
|[[:human genes:c:cct7|CCT7]]|0.444|
|[[:human genes:t:trmt5|TRMT5]]|0.443|
|[[:human genes:m:mrps6|MRPS6]]|0.443|
|[[:human genes:s:sars2|SARS2]]|0.442|
|[[:human genes:c:c10orf2|C10orf2]]|0.442|
|[[:human genes:d:dap3|DAP3]]|0.442|
|[[:human genes:t:tmem41b|TMEM41B]]|0.442|
|[[:human genes:t:taz|TAZ]]|0.441|
|[[:human genes:p:pgm3|PGM3]]|0.439|
|[[:human genes:a:alg6|ALG6]]|0.438|
|[[:human genes:w:wdr59|WDR59]]|0.437|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.437|
|[[:human genes:r:rpe|RPE]]|0.436|
|[[:human genes:n:nxt1|NXT1]]|0.436|
|[[:human genes:t:tti1|TTI1]]|0.435|
|[[:human genes:m:mllt1|MLLT1]]|0.434|
|[[:human genes:t:timm13|TIMM13]]|0.433|
|[[:human genes:s:srd5a3|SRD5A3]]|0.433|
|[[:human genes:p:pnpt1|PNPT1]]|0.432|
|[[:human genes:m:mrps26|MRPS26]]|0.431|
|[[:human genes:e:eef1e1|EEF1E1]]|0.431|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.43|
|[[:human genes:t:trnt1|TRNT1]]|0.429|
|[[:human genes:s:slc35b1|SLC35B1]]|0.428|
|[[:human genes:a:atp5e|ATP5E]]|0.428|
|[[:human genes:r:romo1|ROMO1]]|0.427|
|[[:human genes:c:chchd4|CHCHD4]]|0.427|
|[[:human genes:p:ppp4c|PPP4C]]|0.426|
|[[:human genes:d:dpf2|DPF2]]|0.426|
|[[:human genes:t:trmt10a|TRMT10A]]|0.425|
|[[:human genes:w:wdr24|WDR24]]|0.424|
|[[:human genes:d:dr1|DR1]]|0.424|
|[[:human genes:c:cox7b|COX7B]]|0.423|
|[[:human genes:s:sec16a|SEC16A]]|0.423|
|[[:human genes:p:pelo|PELO]]|0.423|
|[[:human genes:t:tsen34|TSEN34]]|0.423|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.422|
|[[:human genes:m:med4|MED4]]|0.422|
|[[:human genes:m:mrps34|MRPS34]]|0.422|
|[[:human genes:g:gabpa|GABPA]]|0.422|
|[[:human genes:p:pdss1|PDSS1]]|0.421|
|[[:human genes:g:gfm1|GFM1]]|0.421|
|[[:human genes:z:zrsr2|ZRSR2]]|0.419|
|[[:human genes:p:ppp6c|PPP6C]]|0.419|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.418|
|[[:human genes:u:ube2k|UBE2K]]|0.417|
|[[:human genes:m:mrpl15|MRPL15]]|0.417|
|[[:human genes:w:wbscr16|WBSCR16]]|0.416|
|[[:human genes:m:mfn1|MFN1]]|0.416|
|[[:human genes:s:serf2|SERF2]]|0.413|
|[[:human genes:m:med25|MED25]]|0.413|
|[[:human genes:s:sec62|SEC62]]|0.412|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.411|
|[[:human genes:u:ufm1|UFM1]]|0.411|
|[[:human genes:v:vars2|VARS2]]|0.409|
|[[:human genes:e:eif4e|EIF4E]]|0.409|
|[[:human genes:d:dhx29|DHX29]]|0.409|
|[[:human genes:m:mrps9|MRPS9]]|0.408|
|[[:human genes:s:sco2|SCO2]]|0.408|
|[[:human genes:s:selrc1|SELRC1]]|0.408|
|[[:human genes:u:ube2j1|UBE2J1]]|0.406|
|[[:human genes:u:urm1|URM1]]|0.405|
|[[:human genes:h:haus8|HAUS8]]|0.405|
|[[:human genes:t:tefm|TEFM]]|0.405|
|[[:human genes:d:dad1|DAD1]]|0.405|
|[[:human genes:g:gfer|GFER]]|0.404|
|[[:human genes:v:vmp1|VMP1]]|0.404|
|[[:human genes:p:ppcs|PPCS]]|0.402|
|[[:human genes:m:march5|MARCH5]]|0.402|
|[[:human genes:s:sdha|SDHA]]|0.402|
|[[:human genes:u:uqcrq|UQCRQ]]|0.401|
|[[:human genes:u:ubqln1|UBQLN1]]|0.401|
|[[:human genes:t:tbp|TBP]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5751
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP5J Expression in NALM6 Cells: 5.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>