ATP5L [The Human Chemical-Genetic Interaction Map Project]

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======= ATP5L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP5MG
  * **<color #00a2e8>Official Name</color>**: ATP synthase membrane subunit g
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10632|10632]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75964|O75964]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP5L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP5L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617473|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ATP-synt G|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)|
|mitochondrial proton-transporting ATP synthase complex|
|proton-transporting ATP synthase activity, rotational mechanism|
|mitochondrial ATP synthesis coupled proton transport|
|energy coupled proton transport, down electrochemical gradient|
|ATP synthesis coupled proton transport|
|cristae formation|
|ATP biosynthetic process|
|inner mitochondrial membrane organization|
|purine ribonucleoside triphosphate biosynthetic process|
|purine nucleoside triphosphate biosynthetic process|
|ribonucleoside triphosphate biosynthetic process|
|purine ribonucleoside triphosphate metabolic process|
|transmembrane transporter activity|
|nucleoside triphosphate biosynthetic process|
|ribonucleoside triphosphate metabolic process|
|purine nucleoside triphosphate metabolic process|
|mitochondrial transmembrane transport|
|nucleoside triphosphate metabolic process|
|oxidative phosphorylation|
|mitochondrial membrane organization|
|proton transmembrane transport|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|ATP metabolic process|
|mitochondrial transport|
|ATPase activity|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|mitochondrial inner membrane|
|monovalent inorganic cation transport|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|drug metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|carbohydrate derivative biosynthetic process|
|inorganic ion transmembrane transport|
|cation transport|
|membrane organization|
|organophosphate metabolic process|
|ion transmembrane transport|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|transmembrane transport|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|ion transport|
|organonitrogen compound biosynthetic process|
|intracellular transport|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.74|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.76|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.77|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.78|
|[[:results:exp539|42°C R08 exp539]]|1.79|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.79|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.81|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|1.82|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.86|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.89|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.9|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.93|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.99|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|1.99|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.07|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|2.09|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.09|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.1|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.1|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.11|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.18|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.31|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|2.5|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.54|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.55|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.65|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|2.71|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|2.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atp5a1|ATP5A1]]|0.644|
|[[:human genes:a:atp5b|ATP5B]]|0.614|
|[[:human genes:a:atp5o|ATP5O]]|0.603|
|[[:human genes:a:atp5d|ATP5D]]|0.583|
|[[:human genes:a:atp5c1|ATP5C1]]|0.552|
|[[:human genes:a:atp5f1|ATP5F1]]|0.543|
|[[:human genes:a:atp5i|ATP5I]]|0.516|
|[[:human genes:a:atp5e|ATP5E]]|0.495|
|[[:human genes:a:atp5h|ATP5H]]|0.479|
|[[:human genes:o:opa1|OPA1]]|0.466|
|[[:human genes:t:triap1|TRIAP1]]|0.464|
|[[:human genes:a:atp5j|ATP5J]]|0.461|
|[[:human genes:d:dohh|DOHH]]|0.46|
|[[:human genes:b:bcs1l|BCS1L]]|0.457|
|[[:human genes:d:dap3|DAP3]]|0.448|
|[[:human genes:a:atp5j2|ATP5J2]]|0.443|
|[[:human genes:d:dars2|DARS2]]|0.437|
|[[:human genes:t:tmem242|TMEM242]]|0.435|
|[[:human genes:s:sco2|SCO2]]|0.435|
|[[:human genes:p:pnpt1|PNPT1]]|0.425|
|[[:human genes:u:ube2g2|UBE2G2]]|0.422|
|[[:human genes:y:yars2|YARS2]]|0.419|
|[[:human genes:h:hccs|HCCS]]|0.418|
|[[:human genes:p:pars2|PARS2]]|0.418|
|[[:human genes:f:fh|FH]]|0.416|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.414|
|[[:human genes:w:wbscr16|WBSCR16]]|0.412|
|[[:human genes:k:kdsr|KDSR]]|0.408|
|[[:human genes:m:mfn1|MFN1]]|0.408|
|[[:human genes:c:cox16|COX16]]|0.407|
|[[:human genes:m:mrpl21|MRPL21]]|0.405|
|[[:human genes:c:cycs|CYCS]]|0.404|
|[[:human genes:m:mrpl47|MRPL47]]|0.403|
|[[:human genes:s:serf2|SERF2]]|0.401|
|[[:human genes:c:cox7b|COX7B]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 516
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP5L Expression in NALM6 Cells: 6.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>