ATP5O [The Human Chemical-Genetic Interaction Map Project]

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======= ATP5O =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP5PO
  * **<color #00a2e8>Official Name</color>**: ATP synthase peripheral stalk subunit OSCP
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=539|539]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P48047|P48047]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP5O&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP5O|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600828|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|OSCP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial proton-transporting ATP synthase complex|
|proton-transporting ATP synthase activity, rotational mechanism|
|mitochondrial ATP synthesis coupled proton transport|
|energy coupled proton transport, down electrochemical gradient|
|ATP synthesis coupled proton transport|
|cristae formation|
|ATP biosynthetic process|
|inner mitochondrial membrane organization|
|purine ribonucleoside triphosphate biosynthetic process|
|purine nucleoside triphosphate biosynthetic process|
|ribonucleoside triphosphate biosynthetic process|
|drug binding|
|purine ribonucleoside triphosphate metabolic process|
|transmembrane transporter activity|
|nucleoside triphosphate biosynthetic process|
|ribonucleoside triphosphate metabolic process|
|purine nucleoside triphosphate metabolic process|
|mitochondrial transmembrane transport|
|nucleoside triphosphate metabolic process|
|oxidative phosphorylation|
|mitochondrial membrane organization|
|proton transmembrane transport|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|ATP metabolic process|
|mitochondrial transport|
|ATPase activity|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|mitochondrial inner membrane|
|monovalent inorganic cation transport|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|drug metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|carbohydrate derivative biosynthetic process|
|inorganic ion transmembrane transport|
|cation transport|
|membrane organization|
|organophosphate metabolic process|
|ion transmembrane transport|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|transmembrane transport|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|ion transport|
|organonitrogen compound biosynthetic process|
|intracellular transport|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-1.99|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-1.88|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.86|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|-1.75|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.7|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.72|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.73|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|1.76|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.76|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.77|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.82|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.85|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.88|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.89|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.9|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.94|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.94|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.98|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.01|
|[[:results:exp539|42°C R08 exp539]]|2.05|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.06|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.08|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.09|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.19|
|[[:results:exp275|Citral 75μM R06 exp275]]|2.19|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|2.2|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.25|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.33|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.45|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.52|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.53|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.53|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.58|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.58|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.93|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.97|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atp5b|ATP5B]]|0.844|
|[[:human genes:a:atp5a1|ATP5A1]]|0.764|
|[[:human genes:a:atp5d|ATP5D]]|0.73|
|[[:human genes:a:atp5c1|ATP5C1]]|0.687|
|[[:human genes:a:atp5h|ATP5H]]|0.613|
|[[:human genes:a:atp5l|ATP5L]]|0.603|
|[[:human genes:a:atp5f1|ATP5F1]]|0.596|
|[[:human genes:a:atp5j|ATP5J]]|0.589|
|[[:human genes:t:triap1|TRIAP1]]|0.582|
|[[:human genes:a:atp5e|ATP5E]]|0.578|
|[[:human genes:t:thg1l|THG1L]]|0.575|
|[[:human genes:u:ube2g2|UBE2G2]]|0.573|
|[[:human genes:h:hspd1|HSPD1]]|0.557|
|[[:human genes:a:atp5j2|ATP5J2]]|0.542|
|[[:human genes:b:bcs1l|BCS1L]]|0.54|
|[[:human genes:p:pmm2|PMM2]]|0.54|
|[[:human genes:a:atp5i|ATP5I]]|0.539|
|[[:human genes:d:dpagt1|DPAGT1]]|0.532|
|[[:human genes:f:fh|FH]]|0.531|
|[[:human genes:d:dohh|DOHH]]|0.525|
|[[:human genes:r:romo1|ROMO1]]|0.523|
|[[:human genes:g:gfpt1|GFPT1]]|0.519|
|[[:human genes:s:slc25a26|SLC25A26]]|0.518|
|[[:human genes:m:mbtps2|MBTPS2]]|0.509|
|[[:human genes:t:tmem242|TMEM242]]|0.509|
|[[:human genes:u:uap1|UAP1]]|0.508|
|[[:human genes:a:adsl|ADSL]]|0.504|
|[[:human genes:r:rnmt|RNMT]]|0.503|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.502|
|[[:human genes:m:mrpl21|MRPL21]]|0.502|
|[[:human genes:r:rptor|RPTOR]]|0.501|
|[[:human genes:a:alg1|ALG1]]|0.501|
|[[:human genes:r:rpp21|RPP21]]|0.5|
|[[:human genes:m:med16|MED16]]|0.497|
|[[:human genes:d:dolk|DOLK]]|0.491|
|[[:human genes:g:gmppb|GMPPB]]|0.485|
|[[:human genes:t:trnt1|TRNT1]]|0.483|
|[[:human genes:a:atxn10|ATXN10]]|0.481|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.48|
|[[:human genes:k:kdsr|KDSR]]|0.479|
|[[:human genes:a:alg6|ALG6]]|0.478|
|[[:human genes:t:taz|TAZ]]|0.477|
|[[:human genes:e:eny2|ENY2]]|0.476|
|[[:human genes:d:dars2|DARS2]]|0.476|
|[[:human genes:d:dnajc3|DNAJC3]]|0.474|
|[[:human genes:d:dhps|DHPS]]|0.473|
|[[:human genes:s:ssb|SSB]]|0.473|
|[[:human genes:e:exoc4|EXOC4]]|0.472|
|[[:human genes:p:ppa2|PPA2]]|0.47|
|[[:human genes:a:alg5|ALG5]]|0.469|
|[[:human genes:z:zrsr2|ZRSR2]]|0.468|
|[[:human genes:o:opa1|OPA1]]|0.467|
|[[:human genes:u:uhrf1|UHRF1]]|0.464|
|[[:human genes:c:casp9|CASP9]]|0.464|
|[[:human genes:c:cox16|COX16]]|0.463|
|[[:human genes:v:vezt|VEZT]]|0.462|
|[[:human genes:c:c1orf27|C1orf27]]|0.461|
|[[:human genes:h:hccs|HCCS]]|0.46|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.458|
|[[:human genes:p:pdss1|PDSS1]]|0.456|
|[[:human genes:y:yars2|YARS2]]|0.455|
|[[:human genes:g:gatc|GATC]]|0.455|
|[[:human genes:u:uba5|UBA5]]|0.453|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.451|
|[[:human genes:t:tamm41|TAMM41]]|0.45|
|[[:human genes:c:c17orf89|C17orf89]]|0.45|
|[[:human genes:e:elac2|ELAC2]]|0.45|
|[[:human genes:d:dap3|DAP3]]|0.449|
|[[:human genes:w:wbscr16|WBSCR16]]|0.449|
|[[:human genes:c:cox7b|COX7B]]|0.447|
|[[:human genes:s:sco2|SCO2]]|0.445|
|[[:human genes:p:plaa|PLAA]]|0.444|
|[[:human genes:m:mrps14|MRPS14]]|0.444|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.443|
|[[:human genes:s:sec62|SEC62]]|0.442|
|[[:human genes:s:slc25a3|SLC25A3]]|0.442|
|[[:human genes:p:pnpt1|PNPT1]]|0.441|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.441|
|[[:human genes:s:sdha|SDHA]]|0.44|
|[[:human genes:t:trmt10a|TRMT10A]]|0.44|
|[[:human genes:m:mrp63|MRP63]]|0.44|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.44|
|[[:human genes:r:rtcb|RTCB]]|0.439|
|[[:human genes:c:cbfb|CBFB]]|0.439|
|[[:human genes:f:faf2|FAF2]]|0.437|
|[[:human genes:c:cycs|CYCS]]|0.437|
|[[:human genes:s:selrc1|SELRC1]]|0.437|
|[[:human genes:n:ndufb3|NDUFB3]]|0.437|
|[[:human genes:m:mrps26|MRPS26]]|0.436|
|[[:human genes:m:mrpl20|MRPL20]]|0.436|
|[[:human genes:t:timm22|TIMM22]]|0.434|
|[[:human genes:b:bap1|BAP1]]|0.434|
|[[:human genes:p:ppp6c|PPP6C]]|0.433|
|[[:human genes:t:tmed10|TMED10]]|0.433|
|[[:human genes:t:tmem41b|TMEM41B]]|0.433|
|[[:human genes:s:slc35b1|SLC35B1]]|0.432|
|[[:human genes:s:slc25a52|SLC25A52]]|0.431|
|[[:human genes:a:apaf1|APAF1]]|0.431|
|[[:human genes:t:timm13|TIMM13]]|0.431|
|[[:human genes:d:ddx1|DDX1]]|0.43|
|[[:human genes:z:zbtb11|ZBTB11]]|0.428|
|[[:human genes:a:alg13|ALG13]]|0.427|
|[[:human genes:c:c10orf2|C10orf2]]|0.427|
|[[:human genes:t:tsen54|TSEN54]]|0.425|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.425|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.424|
|[[:human genes:m:mrps16|MRPS16]]|0.423|
|[[:human genes:u:urm1|URM1]]|0.422|
|[[:human genes:t:tufm|TUFM]]|0.422|
|[[:human genes:u:ufm1|UFM1]]|0.42|
|[[:human genes:p:pelo|PELO]]|0.42|
|[[:human genes:m:mrpl47|MRPL47]]|0.42|
|[[:human genes:v:vmp1|VMP1]]|0.419|
|[[:human genes:a:alg2|ALG2]]|0.418|
|[[:human genes:e:elp3|ELP3]]|0.418|
|[[:human genes:m:mrps21|MRPS21]]|0.417|
|[[:human genes:g:gfm1|GFM1]]|0.415|
|[[:human genes:t:trmt5|TRMT5]]|0.415|
|[[:human genes:t:tefm|TEFM]]|0.412|
|[[:human genes:n:ndufb1|NDUFB1]]|0.409|
|[[:human genes:r:rft1|RFT1]]|0.409|
|[[:human genes:d:dhrsx|DHRSX]]|0.409|
|[[:human genes:r:rpusd4|RPUSD4]]|0.408|
|[[:human genes:m:mrps34|MRPS34]]|0.408|
|[[:human genes:n:naf1|NAF1]]|0.406|
|[[:human genes:u:ufsp2|UFSP2]]|0.406|
|[[:human genes:p:pars2|PARS2]]|0.405|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.405|
|[[:human genes:v:vars2|VARS2]]|0.405|
|[[:human genes:c:crls1|CRLS1]]|0.404|
|[[:human genes:c:cept1|CEPT1]]|0.403|
|[[:human genes:p:pgm3|PGM3]]|0.403|
|[[:human genes:t:tti1|TTI1]]|0.403|
|[[:human genes:g:gnb1l|GNB1L]]|0.401|
|[[:human genes:c:ccdc101|CCDC101]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 7/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|1/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1640
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP5O Expression in NALM6 Cells: 6.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>