ATP6V1B2 [The Human Chemical-Genetic Interaction Map Project]

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======= ATP6V1B2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP6V1B2
  * **<color #00a2e8>Official Name</color>**: ATPase H+ transporting V1 subunit B2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=526|526]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P21281|P21281]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP6V1B2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP6V1B2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606939|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ATP-synt ab C|
|ATP-synt ab N|
|ATP-synt ab|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|proton-transporting V-type ATPase, V1 domain|
|proton transmembrane transporter activity|
|proton-transporting ATPase activity, rotational mechanism|
|phagosome acidification|
|transferrin transport|
|phagosome maturation|
|intracellular pH reduction|
|pH reduction|
|microvillus|
|iron ion transport|
|endomembrane system|
|hydrolase activity|
|regulation of intracellular pH|
|insulin receptor signaling pathway|
|regulation of cellular pH|
|ruffle|
|regulation of pH|
|melanosome|
|cellular monovalent inorganic cation homeostasis|
|transition metal ion transport|
|monovalent inorganic cation homeostasis|
|proton transmembrane transport|
|cellular response to insulin stimulus|
|regulation of macroautophagy|
|ATP metabolic process|
|response to insulin|
|cellular response to peptide hormone stimulus|
|lysosomal membrane|
|apical plasma membrane|
|cellular response to peptide|
|regulation of autophagy|
|response to peptide hormone|
|monovalent inorganic cation transport|
|response to peptide|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|inorganic cation transmembrane transport|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cation transmembrane transport|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|intracellular membrane-bounded organelle|
|cation homeostasis|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|regulation of cellular catabolic process|
|cellular homeostasis|
|response to hormone|
|ion transmembrane transport|
|regulation of catabolic process|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|chemical homeostasis|
|cellular response to endogenous stimulus|
|transmembrane transport|
|ion transport|
|response to endogenous stimulus|
|ATP binding|
|protein transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|establishment of protein localization|
|homeostatic process|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp17|DABN 20μM R00 exp17]]|-3.88|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-3.19|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2.92|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-2.71|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-2.56|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-2.48|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-2.4|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-2.32|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.3|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-2.3|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2.25|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-2.04|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.04|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.629|
|[[:human genes:p:prim1|PRIM1]]|0.555|
|[[:human genes:i:ik|IK]]|0.522|
|[[:human genes:v:vps28|VPS28]]|0.519|
|[[:human genes:t:tyms|TYMS]]|0.515|
|[[:human genes:t:tceb3c|TCEB3C]]|0.501|
|[[:human genes:r:rpl35|RPL35]]|0.496|
|[[:human genes:p:polr2j3|POLR2J3]]|0.496|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.494|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.494|
|[[:human genes:a:aatf|AATF]]|0.493|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.493|
|[[:human genes:m:mtch2|MTCH2]]|0.492|
|[[:human genes:p:psmb4|PSMB4]]|0.492|
|[[:human genes:n:nsf|NSF]]|0.484|
|[[:human genes:n:nipbl|NIPBL]]|0.483|
|[[:human genes:e:exosc9|EXOSC9]]|0.481|
|[[:human genes:c:chd4|CHD4]]|0.479|
|[[:human genes:a:atp6v1e1|ATP6V1E1]]|0.479|
|[[:human genes:t:timeless|TIMELESS]]|0.476|
|[[:human genes:o:osbp|OSBP]]|0.469|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.469|
|[[:human genes:c:ccdc116|CCDC116]]|0.466|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.465|
|[[:human genes:t:trappc11|TRAPPC11]]|0.461|
|[[:human genes:s:supt5h|SUPT5H]]|0.457|
|[[:human genes:p:pan3|PAN3]]|0.456|
|[[:human genes:c:ctage4|CTAGE4]]|0.455|
|[[:human genes:c:chmp4b|CHMP4B]]|0.454|
|[[:human genes:n:nup153|NUP153]]|0.454|
|[[:human genes:p:pdcd7|PDCD7]]|0.452|
|[[:human genes:z:znf830|ZNF830]]|0.45|
|[[:human genes:r:ranbp2|RANBP2]]|0.448|
|[[:human genes:r:rrp7a|RRP7A]]|0.448|
|[[:human genes:e:exosc6|EXOSC6]]|0.447|
|[[:human genes:p:psmb2|PSMB2]]|0.443|
|[[:human genes:c:cln6|CLN6]]|0.442|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.44|
|[[:human genes:n:narfl|NARFL]]|0.44|
|[[:human genes:e:exosc3|EXOSC3]]|0.438|
|[[:human genes:c:chaf1a|CHAF1A]]|0.437|
|[[:human genes:t:tsg101|TSG101]]|0.437|
|[[:human genes:c:ctage9|CTAGE9]]|0.436|
|[[:human genes:g:gid4|GID4]]|0.436|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.433|
|[[:human genes:c:cactin|CACTIN]]|0.432|
|[[:human genes:s:strn|STRN]]|0.429|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.428|
|[[:human genes:r:rpl30|RPL30]]|0.427|
|[[:human genes:r:rrm2|RRM2]]|0.427|
|[[:human genes:s:skiv2l2|SKIV2L2]]|0.425|
|[[:human genes:u:usp37|USP37]]|0.424|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.424|
|[[:human genes:s:sart1|SART1]]|0.424|
|[[:human genes:s:slc4a1|SLC4A1]]|0.423|
|[[:human genes:c:cep192|CEP192]]|0.423|
|[[:human genes:s:slc6a17|SLC6A17]]|0.421|
|[[:human genes:t:trappc5|TRAPPC5]]|0.419|
|[[:human genes:c:copg1|COPG1]]|0.418|
|[[:human genes:c:cdk9|CDK9]]|0.414|
|[[:human genes:p:prpf19|PRPF19]]|0.413|
|[[:human genes:c:copb1|COPB1]]|0.412|
|[[:human genes:t:tmem199|TMEM199]]|0.411|
|[[:human genes:p:polr2d|POLR2D]]|0.411|
|[[:human genes:w:wdr75|WDR75]]|0.409|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.409|
|[[:human genes:t:tspy2|TSPY2]]|0.408|
|[[:human genes:c:ccna2|CCNA2]]|0.408|
|[[:human genes:m:med14|MED14]]|0.408|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.407|
|[[:human genes:u:upf1|UPF1]]|0.407|
|[[:human genes:s:snip1|SNIP1]]|0.407|
|[[:human genes:h:heatr1|HEATR1]]|0.405|
|[[:human genes:t:twistnb|TWISTNB]]|0.405|
|[[:human genes:t:tuba8|TUBA8]]|0.404|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.404|
|[[:human genes:c:cdca5|CDCA5]]|0.404|
|[[:human genes:k:krt78|KRT78]]|0.402|
|[[:human genes:o:orc1|ORC1]]|0.402|
|[[:human genes:f:fam25b|FAM25B]]|0.401|
|[[:human genes:d:dhx38|DHX38]]|0.4|
|[[:human genes:v:vps54|VPS54]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 717/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|26/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|73/75|
|lymphocyte|16/16|
|ovary|24/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 156
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP6V1B2 Expression in NALM6 Cells: 6.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>