AVP [The Human Chemical-Genetic Interaction Map Project]

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======= AVP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AVP
  * **<color #00a2e8>Official Name</color>**: arginine vasopressin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=551|551]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01185|P01185]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AVP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AVP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/192340|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the vasopressin/oxytocin family and preproprotein that is proteolytically processed to generate multiple protein products. These products include the neuropeptide hormone arginine vasopressin, and two other peptides, neurophysin 2 and copeptin. Arginine vasopressin is a posterior pituitary hormone that is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin 2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. Mutations in this gene cause autosomal dominant neurohypophyseal diabetes insipidus (ADNDI). This gene is present in a gene cluster with the related gene oxytocin on chromosome 20. [provided by RefSeq, Nov 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Neurophysin 2 specifically binds vasopressin.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hormone 5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|V1B vasopressin receptor binding|
|neurohypophyseal hormone activity|
|V1A vasopressin receptor binding|
|penile erection|
|maternal aggressive behavior|
|negative regulation of female receptivity|
|positive regulation of cellular pH reduction|
|regulation of cellular pH reduction|
|positive regulation of prostaglandin biosynthetic process|
|negative regulation of transmission of nerve impulse|
|regulation of female receptivity|
|positive regulation of unsaturated fatty acid biosynthetic process|
|aggressive behavior|
|female mating behavior|
|hyperosmotic salinity response|
|regulation of prostaglandin biosynthetic process|
|positive regulation of glutamate secretion|
|regulation of unsaturated fatty acid biosynthetic process|
|parental behavior|
|maternal behavior|
|positive regulation of systemic arterial blood pressure|
|grooming behavior|
|protein kinase C signaling|
|copulation|
|regulation of glutamate secretion|
|regulation of transmission of nerve impulse|
|positive regulation of amino acid transport|
|positive regulation of fatty acid biosynthetic process|
|negative regulation of release of cytochrome c from mitochondria|
|water transport|
|mating behavior|
|regulation of renal sodium excretion|
|response to salt stress|
|hyperosmotic response|
|regulation of excretion|
|negative regulation of nervous system process|
|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|
|fluid transport|
|ERK1 and ERK2 cascade|
|neuropeptide hormone activity|
|reproductive behavior|
|vasoconstriction|
|positive regulation of vasoconstriction|
|regulation of amino acid transport|
|mating|
|positive regulation of organic acid transport|
|positive regulation of fatty acid metabolic process|
|renal water homeostasis|
|positive regulation of amine transport|
|regulation of renal system process|
|positive regulation of blood pressure|
|response to testosterone|
|negative regulation of blood vessel diameter|
|regulation of fatty acid biosynthetic process|
|regulation of release of cytochrome c from mitochondria|
|response to nicotine|
|positive regulation of anion transport|
|social behavior|
|intraspecies interaction between organisms|
|negative regulation of mitochondrion organization|
|clathrin-coated vesicle membrane|
|regulation of vasoconstriction|
|regulation of organic acid transport|
|multicellular organismal water homeostasis|
|multi-organism behavior|
|positive regulation of blood circulation|
|water homeostasis|
|response to osmotic stress|
|positive regulation of lipid biosynthetic process|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of intracellular pH|
|secretory granule|
|regulation of fatty acid metabolic process|
|negative regulation of cysteine-type endopeptidase activity|
|regulation of cellular pH|
|regulation of systemic arterial blood pressure|
|regulation of amine transport|
|regulation of anion transport|
|regulation of pH|
|positive regulation of peptidyl-serine phosphorylation|
|cellular monovalent inorganic cation homeostasis|
|renal system process|
|response to ethanol|
|regulation of nervous system process|
|regulation of peptidyl-serine phosphorylation|
|positive regulation of small molecule metabolic process|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|monovalent inorganic cation homeostasis|
|regulation of tube size|
|positive regulation of lipid metabolic process|
|positive regulation of cell growth|
|vascular process in circulatory system|
|regulation of cellular ketone metabolic process|
|regulation of mitochondrion organization|
|regulation of blood pressure|
|regulation of lipid biosynthetic process|
|response to ketone|
|locomotory behavior|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of apoptotic signaling pathway|
|response to alcohol|
|protein kinase activity|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|positive regulation of growth|
|positive regulation of ion transport|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|response to antibiotic|
|multicellular organismal homeostasis|
|regulation of cytosolic calcium ion concentration|
|signaling receptor binding|
|negative regulation of proteolysis|
|MAPK cascade|
|negative regulation of organelle organization|
|blood circulation|
|signal transduction by protein phosphorylation|
|circulatory system process|
|regulation of lipid metabolic process|
|regulation of apoptotic signaling pathway|
|positive regulation of secretion by cell|
|regulation of cell growth|
|regulation of endopeptidase activity|
|dendrite|
|generation of precursor metabolites and energy|
|regulation of small molecule metabolic process|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|regulation of peptidase activity|
|calcium ion homeostasis|
|negative regulation of hydrolase activity|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|regulation of body fluid levels|
|response to toxic substance|
|regulation of anatomical structure size|
|cellular metal ion homeostasis|
|behavior|
|regulation of system process|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|regulation of growth|
|regulation of ion transport|
|negative regulation of cellular component organization|
|cation homeostasis|
|inorganic ion homeostasis|
|regulation of proteolysis|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|ion homeostasis|
|negative regulation of catalytic activity|
|regulation of secretion|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|response to lipid|
|membrane organization|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|apoptotic process|
|protein phosphorylation|
|positive regulation of transport|
|negative regulation of cell death|
|multi-organism reproductive process|
|positive regulation of protein phosphorylation|
|response to drug|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|positive regulation of phosphorylation|
|cell death|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|phosphorylation|
|regulation of organelle organization|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|regulation of transport|
|extracellular region|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9964
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AVP Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>