AXIN1 [The Human Chemical-Genetic Interaction Map Project]

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======= AXIN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AXIN1
  * **<color #00a2e8>Official Name</color>**: axin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8312|8312]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15169|O15169]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AXIN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AXIN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603816|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684). {ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17210684, ECO:0000269|PubMed:27098453}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RGS|
|Axin b-cat bind|
|DIX|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|beta-catenin destruction complex assembly|
|armadillo repeat domain binding|
|I-SMAD binding|
|signaling adaptor activity|
|beta-catenin destruction complex|
|beta-catenin destruction complex disassembly|
|positive regulation of peptidyl-threonine phosphorylation|
|positive regulation of ubiquitin-protein transferase activity|
|cell periphery|
|regulation of intracellular estrogen receptor signaling pathway|
|regulation of peptidyl-threonine phosphorylation|
|molecular adaptor activity|
|regulation of ubiquitin-protein transferase activity|
|SMAD binding|
|lateral plasma membrane|
|regulation of intracellular steroid hormone receptor signaling pathway|
|beta-catenin binding|
|canonical Wnt signaling pathway|
|positive regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of peptidyl-serine phosphorylation|
|positive regulation of protein ubiquitination|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein modification by small protein conjugation or removal|
|regulation of peptidyl-serine phosphorylation|
|positive regulation of JNK cascade|
|positive regulation of cellular protein catabolic process|
|positive regulation of canonical Wnt signaling pathway|
|regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|negative regulation of canonical Wnt signaling pathway|
|positive regulation of Wnt signaling pathway|
|regulation of JNK cascade|
|regulation of protein ubiquitination|
|negative regulation of Wnt signaling pathway|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein catabolic process|
|regulation of protein modification by small protein conjugation or removal|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|protein-containing complex disassembly|
|regulation of cellular protein catabolic process|
|cytoplasmic vesicle|
|regulation of canonical Wnt signaling pathway|
|ubiquitin protein ligase binding|
|activation of protein kinase activity|
|enzyme binding|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|positive regulation of proteolysis|
|regulation of Wnt signaling pathway|
|positive regulation of cellular catabolic process|
|regulation of protein catabolic process|
|cellular component disassembly|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|positive regulation of catabolic process|
|protein kinase binding|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|positive regulation of kinase activity|
|positive regulation of transferase activity|
|perinuclear region of cytoplasm|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|regulation of protein kinase activity|
|regulation of cellular catabolic process|
|cellular protein-containing complex assembly|
|regulation of kinase activity|
|protein homodimerization activity|
|apoptotic process|
|regulation of transferase activity|
|regulation of catabolic process|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|positive regulation of phosphorylation|
|identical protein binding|
|cell death|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|positive regulation of transcription, DNA-templated|
|protein-containing complex assembly|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.66|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.5|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-1.93|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|1.71|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.73|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.75|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.81|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|1.81|
|[[:results:exp331|A-769662 20μM R07 exp331]]|1.87|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.87|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|1.9|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.98|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2.01|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|2.02|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.04|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.14|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|2.21|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.31|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|2.33|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|2.47|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.5|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|2.89|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.99|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|3|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|3.09|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|3.22|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|3.35|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:ctnnbip1|CTNNBIP1]]|0.422|
|[[:human genes:s:srrm2|SRRM2]]|0.421|
|[[:human genes:s:samd4b|SAMD4B]]|0.418|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1686
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AXIN1 Expression in NALM6 Cells: 5.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>