AZI1 [The Human Chemical-Genetic Interaction Map Project]

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======= AZI1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CEP131
  * **<color #00a2e8>Official Name</color>**: centrosomal protein 131
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22994|22994]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UPN4|Q9UPN4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AZI1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AZI1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613479|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Acts also as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non- ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). {ECO:0000250|UniProtKB:Q62036, ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:22797915, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:24185901, ECO:0000269|PubMed:24550735, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26616734}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization to centrosome|
|protein localization to microtubule organizing center|
|ciliary transition zone|
|centriolar satellite|
|protein localization to microtubule cytoskeleton|
|protein localization to cytoskeleton|
|intraciliary transport involved in cilium assembly|
|regulation of centrosome duplication|
|intraciliary transport|
|regulation of centrosome cycle|
|intercellular bridge|
|microtubule-based protein transport|
|protein transport along microtubule|
|acrosomal vesicle|
|ciliary basal body-plasma membrane docking|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|ciliary basal body|
|microtubule cytoskeleton|
|positive regulation of intracellular protein transport|
|transport along microtubule|
|microtubule organizing center|
|organelle localization by membrane tethering|
|cytoskeleton-dependent intracellular transport|
|membrane docking|
|microtubule-based transport|
|regulation of microtubule cytoskeleton organization|
|regulation of G2/M transition of mitotic cell cycle|
|positive regulation of intracellular transport|
|regulation of cell cycle G2/M phase transition|
|regulation of microtubule-based process|
|regulation of intracellular protein transport|
|protein-containing complex localization|
|protein-containing complex binding|
|mitotic cell cycle phase transition|
|microtubule-based movement|
|cell cycle phase transition|
|positive regulation of cellular protein localization|
|cilium assembly|
|regulation of intracellular transport|
|cilium organization|
|regulation of mitotic cell cycle phase transition|
|positive regulation of protein transport|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|cell projection assembly|
|positive regulation of establishment of protein localization|
|centrosome|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|spermatogenesis|
|male gamete generation|
|organelle localization|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|microtubule-based process|
|mitotic cell cycle|
|intracellular membrane-bounded organelle|
|gamete generation|
|regulation of protein transport|
|protein localization to organelle|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of cell cycle process|
|organelle assembly|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|protein homodimerization activity|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|positive regulation of transport|
|multi-organism reproductive process|
|intracellular protein transport|
|cell cycle process|
|regulation of protein localization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of cell cycle|
|regulation of organelle organization|
|cell cycle|
|reproductive process|
|reproduction|
|protein transport|
|intracellular transport|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell population proliferation|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.85|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|1.8|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.59|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 178/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|6/28|
|blood|8/28|
|bone|9/26|
|breast|11/33|
|central nervous system|16/56|
|cervix|2/4|
|colorectal|5/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|4/21|
|liver|6/20|
|lung|15/75|
|lymphocyte|1/16|
|ovary|7/26|
|pancreas|5/24|
|peripheral nervous system|9/16|
|plasma cell|6/15|
|prostate|1/1|
|skin|7/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|4/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4313
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AZI1 Expression in NALM6 Cells: 4.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>