B3GAT3 [The Human Chemical-Genetic Interaction Map Project]

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======= B3GAT3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: B3GAT3
  * **<color #00a2e8>Official Name</color>**: beta-1,3-glucuronyltransferase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26229|26229]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94766|O94766]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=B3GAT3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20B3GAT3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606374|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the glucuronyltransferase gene family, enzymes that exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product catalyzes the formation of the glycosaminoglycan-protein linkage by way of a glucuronyl transfer reaction in the final step of the biosynthesis of the linkage region of proteoglycans. A pseudogene of this gene has been identified on chromosome 3. [provided by RefSeq, Dec 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Glycosaminoglycans biosynthesis (PubMed:25893793). Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4- Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Shows strict specificity for Gal-beta-1,3-Gal-beta-1,4-Xyl, exhibiting negligible incorporation into other galactoside substrates including Galbeta1-3Gal beta1-O-benzyl, Galbeta1- 4GlcNAc and Galbeta1-4Glc. Stimulates 2-phosphoxylose phosphatase activity of PXYLP1 in presence of uridine diphosphate-glucuronic acid (UDP-GlcUA) during completion of linkage region formation (PubMed:24425863). {ECO:0000269|PubMed:24425863, ECO:0000269|PubMed:25893793}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glyco transf 43|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|
|protein phosphatase activator activity|
|dermatan sulfate proteoglycan biosynthetic process|
|dermatan sulfate proteoglycan metabolic process|
|glucuronosyltransferase activity|
|heparan sulfate proteoglycan biosynthetic process|
|chondroitin sulfate proteoglycan biosynthetic process|
|heparan sulfate proteoglycan metabolic process|
|chondroitin sulfate proteoglycan metabolic process|
|cis-Golgi network|
|proteoglycan biosynthetic process|
|proteoglycan metabolic process|
|glycosaminoglycan biosynthetic process|
|aminoglycan biosynthetic process|
|regulation of phosphoprotein phosphatase activity|
|regulation of protein dephosphorylation|
|positive regulation of intracellular protein transport|
|glycosaminoglycan metabolic process|
|aminoglycan metabolic process|
|regulation of phosphatase activity|
|positive regulation of intracellular transport|
|regulation of dephosphorylation|
|regulation of intracellular protein transport|
|protein glycosylation|
|macromolecule glycosylation|
|glycosylation|
|glycoprotein biosynthetic process|
|positive regulation of cellular protein localization|
|regulation of intracellular transport|
|glycoprotein metabolic process|
|positive regulation of protein transport|
|positive regulation of establishment of protein localization|
|regulation of cellular protein localization|
|Golgi membrane|
|carbohydrate derivative biosynthetic process|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of cellular localization|
|Golgi apparatus|
|positive regulation of transport|
|regulation of protein localization|
|carbohydrate derivative metabolic process|
|regulation of hydrolase activity|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.78|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-1.73|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|2.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:papss1|PAPSS1]]|0.426|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6607
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='B3GAT3 Expression in NALM6 Cells: 5.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>