B3GNT6 [The Human Chemical-Genetic Interaction Map Project]

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======= B3GNT6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: B3GNT6
  * **<color #00a2e8>Official Name</color>**: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=192134|192134]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6ZMB0|Q6ZMB0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=B3GNT6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20B3GNT6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615315|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a beta-1,3-N-acetylglucosaminyltransferase that adds an N-acetylglucosamine moiety to N-acetylgalactosamine-modified serine or threonine. The encoded enzyme is responsible for creating the core 3 structure of O-glycans, which are important components of mucin-type glycoproteins. [provided by RefSeq, Dec 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Beta-1,3-N-acetylglucosaminyltransferase that synthesizes the core 3 structure of the O-glycan, an important precursor in the biosynthesis of mucin-type glycoproteins. Plays an important role in the synthesis of mucin-type O-glycans in digestive organs.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Galactosyl T|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|O-glycan processing, core 3|
|acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity|
|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity|
|N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity|
|poly-N-acetyllactosamine biosynthetic process|
|poly-N-acetyllactosamine metabolic process|
|galactosyltransferase activity|
|acetylgalactosaminyltransferase activity|
|polysaccharide biosynthetic process|
|cellular polysaccharide biosynthetic process|
|cellular carbohydrate biosynthetic process|
|O-glycan processing|
|cellular polysaccharide metabolic process|
|polysaccharide metabolic process|
|aminoglycan biosynthetic process|
|protein O-linked glycosylation|
|carbohydrate biosynthetic process|
|aminoglycan metabolic process|
|cellular carbohydrate metabolic process|
|macromolecule glycosylation|
|protein glycosylation|
|glycosylation|
|glycoprotein biosynthetic process|
|glycoprotein metabolic process|
|carbohydrate metabolic process|
|carbohydrate derivative biosynthetic process|
|Golgi membrane|
|Golgi apparatus|
|endoplasmic reticulum|
|carbohydrate derivative metabolic process|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|1.74|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|1.8|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6556
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.22 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='B3GNT6 Expression in NALM6 Cells: 1.22'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>