BAIAP2 [The Human Chemical-Genetic Interaction Map Project]

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======= BAIAP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BAIAP2
  * **<color #00a2e8>Official Name</color>**: BAR/IMD domain containing adaptor protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10458|10458]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UQB8|Q9UQB8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BAIAP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BAIAP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605475|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. {ECO:0000269|PubMed:11130076, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:14752106, ECO:0000269|PubMed:17115031, ECO:0000269|PubMed:19366662}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IMD|
|SH3 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neuron projection branch point|
|dendritic spine cytoplasm|
|modification of synaptic structure, modulating synaptic transmission|
|cellular response to L-glutamate|
|regulation of modification of postsynaptic actin cytoskeleton|
|transcription cofactor binding|
|regulation of modification of postsynaptic structure|
|actin crosslink formation|
|response to L-glutamate|
|regulation of modification of synaptic structure|
|cytoskeletal adaptor activity|
|presynaptic cytosol|
|modification of synaptic structure|
|postsynaptic cytosol|
|proline-rich region binding|
|postsynaptic density, intracellular component|
|positive regulation of actin cytoskeleton reorganization|
|cadherin binding involved in cell-cell adhesion|
|positive regulation of dendritic spine morphogenesis|
|neuron projection terminus|
|synaptic membrane|
|positive regulation of excitatory postsynaptic potential|
|excitatory synapse|
|dendritic shaft|
|regulation of actin cytoskeleton reorganization|
|positive regulation of dendrite morphogenesis|
|modulation of excitatory postsynaptic potential|
|regulation of dendritic spine morphogenesis|
|cellular response to epidermal growth factor stimulus|
|positive regulation of dendritic spine development|
|response to epidermal growth factor|
|scaffold protein binding|
|rough endoplasmic reticulum|
|actin filament bundle assembly|
|protein localization to synapse|
|positive regulation of nervous system process|
|actin filament bundle organization|
|vascular endothelial growth factor receptor signaling pathway|
|cellular response to nutrient|
|cellular response to amino acid stimulus|
|filopodium|
|regulation of dendritic spine development|
|positive regulation of dendrite development|
|Schaffer collateral - CA1 synapse|
|secretory granule|
|PDZ domain binding|
|insulin receptor signaling pathway|
|regulation of dendrite morphogenesis|
|positive regulation of actin filament polymerization|
|plasma membrane organization|
|ruffle|
|regulation of postsynapse organization|
|dendrite development|
|cell-cell adherens junction|
|response to amino acid|
|positive regulation of protein polymerization|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|regulation of nervous system process|
|Fc receptor mediated stimulatory signaling pathway|
|Fc-gamma receptor signaling pathway|
|regulation of dendrite development|
|positive regulation of synaptic transmission|
|regulation of cell shape|
|positive regulation of cell morphogenesis involved in differentiation|
|cellular response to insulin stimulus|
|regulation of actin filament polymerization|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|protein C-terminus binding|
|regulation of synaptic plasticity|
|positive regulation of supramolecular fiber organization|
|cellular response to acid chemical|
|response to nutrient|
|actin cytoskeleton|
|regulation of synapse organization|
|positive regulation of cytoskeleton organization|
|regulation of protein polymerization|
|response to insulin|
|regulation of synapse structure or activity|
|cellular response to nutrient levels|
|actin filament organization|
|Fc receptor signaling pathway|
|positive regulation of protein complex assembly|
|regulation of actin filament organization|
|cellular response to extracellular stimulus|
|cellular response to peptide hormone stimulus|
|synapse organization|
|positive regulation of neuron projection development|
|regulation of cell morphogenesis involved in differentiation|
|microtubule|
|cellular response to peptide|
|phagocytosis|
|cellular response to external stimulus|
|regulation of actin cytoskeleton organization|
|response to acid chemical|
|glutamatergic synapse|
|regulation of supramolecular fiber organization|
|positive regulation of neuron differentiation|
|axonogenesis|
|neuronal cell body|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|regulation of actin filament-based process|
|response to peptide hormone|
|cellular response to drug|
|axon development|
|endomembrane system organization|
|regulation of membrane potential|
|cell morphogenesis involved in neuron differentiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|immune response-activating cell surface receptor signaling pathway|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|positive regulation of neurogenesis|
|response to peptide|
|neuron projection morphogenesis|
|immune response-regulating cell surface receptor signaling pathway|
|plasma membrane bounded cell projection morphogenesis|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|actin cytoskeleton organization|
|regulation of neuron projection development|
|response to nutrient levels|
|cellular response to growth factor stimulus|
|cell-cell adhesion|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of anatomical structure size|
|cell part morphogenesis|
|positive regulation of cellular component biogenesis|
|response to extracellular stimulus|
|response to growth factor|
|positive regulation of nervous system development|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|cell morphogenesis involved in differentiation|
|immune response-activating signal transduction|
|actin filament-based process|
|regulation of system process|
|immune response-regulating signaling pathway|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|positive regulation of organelle organization|
|activation of immune response|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|neuron projection development|
|response to bacterium|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|brain development|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|membrane organization|
|positive regulation of immune response|
|response to hormone|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|central nervous system development|
|Golgi apparatus|
|response to organonitrogen compound|
|neuron differentiation|
|response to drug|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|response to nitrogen compound|
|immune effector process|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|positive regulation of immune system process|
|regulation of immune response|
|cell projection organization|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|positive regulation of developmental process|
|response to endogenous stimulus|
|generation of neurons|
|response to oxygen-containing compound|
|neurogenesis|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10645
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BAIAP2 Expression in NALM6 Cells: -2.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>