BANK1 [The Human Chemical-Genetic Interaction Map Project]

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======= BANK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BANK1
  * **<color #00a2e8>Official Name</color>**: B cell scaffold protein with ankyrin repeats 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55024|55024]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NDB2|Q8NDB2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BANK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BANK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610292|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. This protein can also promote Lyn-mediated tyrosine phosphorylation of inositol 1,4,5-trisphosphate receptors. Polymorphisms in this gene are associated with susceptibility to systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2. {ECO:0000269|PubMed:11782428}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of interleukin-6 secretion|
|negative regulation of translational initiation|
|protein tyrosine kinase binding|
|negative regulation of B cell activation|
|negative regulation of interleukin-6 production|
|negative regulation of protein kinase B signaling|
|negative regulation of cytokine secretion|
|regulation of translational initiation|
|negative regulation of translation|
|negative regulation of protein secretion|
|negative regulation of peptide secretion|
|regulation of interleukin-6 production|
|negative regulation of lymphocyte activation|
|negative regulation of cellular amide metabolic process|
|B cell activation|
|negative regulation of leukocyte activation|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|positive regulation of peptidyl-tyrosine phosphorylation|
|negative regulation of cell activation|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|regulation of B cell activation|
|regulation of protein kinase B signaling|
|negative regulation of secretion|
|regulation of peptidyl-tyrosine phosphorylation|
|negative regulation of cytokine production|
|signaling receptor binding|
|regulation of translation|
|lymphocyte activation|
|regulation of cellular amide metabolic process|
|negative regulation of immune system process|
|regulation of protein secretion|
|negative regulation of transport|
|regulation of peptide secretion|
|negative regulation of intracellular signal transduction|
|regulation of lymphocyte activation|
|posttranscriptional regulation of gene expression|
|positive regulation of MAPK cascade|
|regulation of leukocyte activation|
|regulation of cell activation|
|response to bacterium|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of secretion|
|leukocyte activation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|cell activation|
|negative regulation of protein metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|regulation of immune system process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|1.73|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|1.74|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7994
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.22 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BANK1 Expression in NALM6 Cells: -0.22'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>