BASP1 [The Human Chemical-Genetic Interaction Map Project]

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======= BASP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BASP1
  * **<color #00a2e8>Official Name</color>**: brain abundant membrane attached signal protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10409|10409]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P80723|P80723]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BASP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BASP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605940|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BASP1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of metanephric ureteric bud development|
|positive regulation of metanephric ureteric bud development|
|thorax and anterior abdomen determination|
|zygotic determination of anterior/posterior axis, embryo|
|diaphragm development|
|positive regulation of metanephros development|
|metanephric mesenchyme development|
|mesenchymal to epithelial transition|
|tripartite regional subdivision|
|anterior/posterior axis specification, embryo|
|renal filtration cell differentiation|
|glomerular visceral epithelial cell differentiation|
|glomerular epithelial cell differentiation|
|kidney mesenchyme development|
|blastoderm segmentation|
|glomerular epithelium development|
|positive regulation of mesonephros development|
|regulation of metanephros development|
|regulation of mesonephros development|
|epithelial cell differentiation involved in kidney development|
|embryonic axis specification|
|COP9 signalosome|
|positive regulation of heart growth|
|positive regulation of kidney development|
|cell differentiation involved in kidney development|
|substantia nigra development|
|positive regulation of organ growth|
|anterior/posterior axis specification|
|glomerulus development|
|regulation of kidney development|
|embryonic pattern specification|
|neural nucleus development|
|regulation of heart growth|
|positive regulation of animal organ morphogenesis|
|metanephros development|
|midbrain development|
|axis specification|
|regulation of organ growth|
|segmentation|
|nephron epithelium development|
|nephron development|
|kidney epithelium development|
|growth cone|
|skeletal muscle organ development|
|vesicle|
|positive regulation of developmental growth|
|respiratory system development|
|gonad development|
|development of primary sexual characteristics|
|anterior/posterior pattern specification|
|transcription regulatory region DNA binding|
|mesenchyme development|
|transcription corepressor activity|
|protein domain specific binding|
|regulation of animal organ morphogenesis|
|positive regulation of growth|
|sex differentiation|
|kidney development|
|renal system development|
|muscle organ development|
|urogenital system development|
|regulation of developmental growth|
|regionalization|
|cytoskeleton|
|nuclear speck|
|reproductive structure development|
|reproductive system development|
|pattern specification process|
|muscle structure development|
|cell junction|
|developmental process involved in reproduction|
|regulation of growth|
|epithelial cell differentiation|
|brain development|
|head development|
|embryo development|
|central nervous system development|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|-1.93|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.82|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-1.78|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.77|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4193
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.35 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BASP1 Expression in NALM6 Cells: -0.35'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>