BAZ1B [The Human Chemical-Genetic Interaction Map Project]

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======= BAZ1B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BAZ1B
  * **<color #00a2e8>Official Name</color>**: bromodomain adjacent to zinc finger domain 1B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9031|9031]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UIG0|Q9UIG0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BAZ1B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BAZ1B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605681|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the bromodomain protein family. The bromodomain is a structural motif characteristic of proteins involved in chromatin-dependent regulation of transcription. This gene is deleted in Williams-Beuren syndrome, a developmental disorder caused by deletion of multiple genes at 7q11.23. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication. {ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:19092802, ECO:0000269|PubMed:19234442}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PHD|
|Bromodomain|
|WAC Acf1 DNA bd|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone kinase activity|
|nuclear replication fork|
|pericentric heterochromatin|
|condensed chromosome|
|histone phosphorylation|
|non-membrane spanning protein tyrosine kinase activity|
|positive regulation of gene expression, epigenetic|
|protein tyrosine kinase activity|
|histone binding|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|chromatin assembly or disassembly|
|chromatin remodeling|
|regulation of gene expression, epigenetic|
|nuclear body|
|histone modification|
|covalent chromatin modification|
|chromatin organization|
|cellular response to DNA damage stimulus|
|zinc ion binding|
|peptidyl-amino acid modification|
|protein phosphorylation|
|chromosome organization|
|phosphorylation|
|ATP binding|
|cellular response to stress|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.16|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-1.79|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-1.77|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|-1.7|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.76|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.83|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.88|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.12|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.52|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2241
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BAZ1B Expression in NALM6 Cells: 8.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>