BCL11B [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= BCL11B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BCL11B
  * **<color #00a2e8>Official Name</color>**: BAF chromatin remodeling complex subunit BCL11B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64919|64919]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9C0K0|Q9C0K0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BCL11B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BCL11B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606558|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Key regulator of both differentiation and survival of T- lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T- lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC- rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611, ECO:0000269|PubMed:27959755}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|olfactory bulb axon guidance|
|lymphoid lineage cell migration into thymus|
|lymphoid lineage cell migration|
|hematopoietic stem cell migration|
|striatal medium spiny neuron differentiation|
|somatic diversification of T cell receptor genes|
|somatic recombination of T cell receptor gene segments|
|T cell receptor V(D)J recombination|
|commitment of neuronal cell to specific neuron type in forebrain|
|post-embryonic camera-type eye development|
|forebrain neuron fate commitment|
|keratinocyte development|
|post-embryonic animal organ development|
|V(D)J recombination|
|striatum development|
|subpallium development|
|positive T cell selection|
|regulation of keratinocyte proliferation|
|epithelial cell morphogenesis|
|somatic diversification of immune receptors via germline recombination within a single locus|
|somatic cell DNA recombination|
|T cell selection|
|thymus development|
|T cell differentiation in thymus|
|somatic diversification of immune receptors|
|alpha-beta T cell differentiation|
|forebrain neuron differentiation|
|alpha-beta T cell activation|
|neuron fate commitment|
|forebrain generation of neurons|
|odontogenesis of dentin-containing tooth|
|post-embryonic development|
|odontogenesis|
|T cell differentiation|
|central nervous system neuron differentiation|
|epithelial cell development|
|DNA recombination|
|T cell activation|
|lymphocyte differentiation|
|cell fate commitment|
|telencephalon development|
|axon guidance|
|neuron projection guidance|
|keratinocyte differentiation|
|camera-type eye development|
|epidermal cell differentiation|
|neuron projection|
|leukocyte differentiation|
|regulation of epithelial cell proliferation|
|eye development|
|visual system development|
|sensory system development|
|axonogenesis|
|skin development|
|lymphocyte activation|
|forebrain development|
|regulation of lipid metabolic process|
|axon development|
|gland development|
|epidermis development|
|sequence-specific DNA binding|
|cell morphogenesis involved in neuron differentiation|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|cell part morphogenesis|
|sensory organ development|
|chemotaxis|
|taxis|
|hemopoiesis|
|cell morphogenesis involved in differentiation|
|hematopoietic or lymphoid organ development|
|immune system development|
|regulation of neuron differentiation|
|neuron projection development|
|DNA-binding transcription factor activity|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|cell morphogenesis|
|brain development|
|DNA metabolic process|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|animal organ morphogenesis|
|cell migration|
|central nervous system development|
|negative regulation of cell death|
|neuron differentiation|
|cell activation|
|cell motility|
|localization of cell|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of transcription by RNA polymerase II|
|locomotion|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of cell death|
|positive regulation of RNA metabolic process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9823
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BCL11B Expression in NALM6 Cells: 1.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>