BCL2L2 [The Human Chemical-Genetic Interaction Map Project]

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======= BCL2L2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BCL2L2
  * **<color #00a2e8>Official Name</color>**: BCL2 like 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=599|599]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92843|Q92843]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BCL2L2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BCL2L2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601931|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. {ECO:0000269|PubMed:8761287}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BH4|
|Bcl-2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|BH domain binding|
|Sertoli cell proliferation|
|Bcl-2 family protein complex|
|signal transduction in absence of ligand|
|extrinsic apoptotic signaling pathway in absence of ligand|
|disordered domain specific binding|
|cellular response to estradiol stimulus|
|cellular response to amyloid-beta|
|response to amyloid-beta|
|intrinsic apoptotic signaling pathway in response to DNA damage|
|epithelial cell proliferation|
|negative regulation of intrinsic apoptotic signaling pathway|
|extrinsic apoptotic signaling pathway|
|male gonad development|
|development of primary male sexual characteristics|
|response to estradiol|
|intrinsic apoptotic signaling pathway|
|male sex differentiation|
|regulation of intrinsic apoptotic signaling pathway|
|mitochondrial outer membrane|
|gonad development|
|development of primary sexual characteristics|
|negative regulation of apoptotic signaling pathway|
|sex differentiation|
|apoptotic signaling pathway|
|cellular response to peptide|
|regulation of apoptotic signaling pathway|
|reproductive structure development|
|reproductive system development|
|response to peptide|
|protein heterodimerization activity|
|negative regulation of intracellular signal transduction|
|cellular response to lipid|
|cellular response to organic cyclic compound|
|spermatogenesis|
|cell population proliferation|
|male gamete generation|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|developmental process involved in reproduction|
|gamete generation|
|cellular response to DNA damage stimulus|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|response to lipid|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|response to organic cyclic compound|
|apoptotic process|
|negative regulation of cell death|
|multi-organism reproductive process|
|response to organonitrogen compound|
|programmed cell death|
|cellular response to oxygen-containing compound|
|identical protein binding|
|response to nitrogen compound|
|cell death|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-1.7|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dnm2|DNM2]]|0.445|
|[[:human genes:z:zfand5|ZFAND5]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2460
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BCL2L2 Expression in NALM6 Cells: 4.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>