BIRC2 [The Human Chemical-Genetic Interaction Map Project]

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======= BIRC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BIRC2
  * **<color #00a2e8>Official Name</color>**: baculoviral IAP repeat containing 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=329|329]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13490|Q13490]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BIRC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BIRC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601712|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin- protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase- dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle. {ECO:0000269|PubMed:15665297, ECO:0000269|PubMed:18082613, ECO:0000269|PubMed:21145488, ECO:0000269|PubMed:21653699, ECO:0000269|PubMed:21931591, ECO:0000269|PubMed:23453969}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CARD|
|BIR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of ripoptosome assembly involved in necroptotic process|
|regulation of ripoptosome assembly involved in necroptotic process|
|positive regulation of protein K48-linked ubiquitination|
|FBXO family protein binding|
|regulation of protein K48-linked ubiquitination|
|positive regulation of protein K63-linked ubiquitination|
|positive regulation of protein monoubiquitination|
|regulation of protein monoubiquitination|
|inhibition of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of nucleotide-binding oligomerization domain containing signaling pathway|
|regulation of protein K63-linked ubiquitination|
|CD40 receptor complex|
|inhibition of cysteine-type endopeptidase activity|
|zymogen inhibition|
|positive regulation of protein polyubiquitination|
|negative regulation of necroptotic process|
|XY body|
|negative regulation of programmed necrotic cell death|
|negative regulation of necrotic cell death|
|regulation of necroptotic process|
|regulation of RIG-I signaling pathway|
|regulation of programmed necrotic cell death|
|regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway|
|regulation of protein polyubiquitination|
|necroptotic process|
|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|
|programmed necrotic cell death|
|TRIF-dependent toll-like receptor signaling pathway|
|regulation of necrotic cell death|
|necrotic cell death|
|MyD88-independent toll-like receptor signaling pathway|
|negative regulation of protein processing|
|negative regulation of protein maturation|
|cytoplasmic side of plasma membrane|
|regulation of tumor necrosis factor-mediated signaling pathway|
|transferase activity|
|regulation of protein processing|
|regulation of protein maturation|
|regulation of toll-like receptor signaling pathway|
|I-kappaB kinase/NF-kappaB signaling|
|regulation of defense response to virus|
|NIK/NF-kappaB signaling|
|ubiquitin binding|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of cysteine-type endopeptidase activity|
|toll-like receptor signaling pathway|
|response to cAMP|
|chaperone binding|
|protein heterooligomerization|
|protein N-terminus binding|
|regulation of NIK/NF-kappaB signaling|
|positive regulation of protein ubiquitination|
|tumor necrosis factor-mediated signaling pathway|
|response to ethanol|
|pattern recognition receptor signaling pathway|
|negative regulation of protein complex assembly|
|positive regulation of protein modification by small protein conjugation or removal|
|response to organophosphorus|
|placenta development|
|response to purine-containing compound|
|regulation of cytokine-mediated signaling pathway|
|regulation of response to cytokine stimulus|
|regulation of reactive oxygen species metabolic process|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of protein ubiquitination|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|ubiquitin protein ligase activity|
|membrane raft|
|regulation of protein modification by small protein conjugation or removal|
|response to alcohol|
|innate immune response-activating signal transduction|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|cellular response to tumor necrosis factor|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|ubiquitin-protein transferase activity|
|negative regulation of peptidase activity|
|activation of innate immune response|
|response to tumor necrosis factor|
|protein deubiquitination|
|transcription coactivator activity|
|protein modification by small protein removal|
|protein polyubiquitination|
|response to antibiotic|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|regulation of inflammatory response|
|positive regulation of innate immune response|
|response to hypoxia|
|proteasomal protein catabolic process|
|negative regulation of proteolysis|
|response to decreased oxygen levels|
|positive regulation of response to biotic stimulus|
|response to oxygen levels|
|regulation of endopeptidase activity|
|reproductive structure development|
|reproductive system development|
|regulation of peptidase activity|
|regulation of protein complex assembly|
|regulation of innate immune response|
|negative regulation of hydrolase activity|
|regulation of immune effector process|
|positive regulation of defense response|
|response to toxic substance|
|positive regulation of multi-organism process|
|protein complex oligomerization|
|regulation of response to biotic stimulus|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|immune response-activating signal transduction|
|proteolysis involved in cellular protein catabolic process|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|cellular protein catabolic process|
|activation of immune response|
|developmental process involved in reproduction|
|cytokine-mediated signaling pathway|
|protein catabolic process|
|protein ubiquitination|
|regulation of cytokine production|
|negative regulation of cellular component organization|
|regulation of proteolysis|
|regulation of defense response|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|negative regulation of catalytic activity|
|zinc ion binding|
|positive regulation of immune response|
|negative regulation of apoptotic process|
|cellular macromolecule catabolic process|
|negative regulation of programmed cell death|
|response to organic cyclic compound|
|apoptotic process|
|regulation of cellular component biogenesis|
|protein modification by small protein conjugation or removal|
|negative regulation of cell death|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|response to drug|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|identical protein binding|
|response to nitrogen compound|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|regulation of cell cycle|
|positive regulation of protein modification process|
|proteolysis|
|regulation of hydrolase activity|
|reproductive process|
|reproduction|
|regulation of response to stress|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-2.62|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2.57|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-2.46|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.44|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.42|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-2.32|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-2.24|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-2.1|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.1|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.02|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-1.93|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-1.88|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-1.86|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.86|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-1.85|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-1.83|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-1.77|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-1.75|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-1.75|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:traf2|TRAF2]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 7/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9253
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BIRC2 Expression in NALM6 Cells: 5.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>