BIRC6 [The Human Chemical-Genetic Interaction Map Project]

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======= BIRC6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BIRC6
  * **<color #00a2e8>Official Name</color>**: baculoviral IAP repeat containing 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57448|57448]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NR09|Q9NR09]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BIRC6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BIRC6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605638|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UQ con|
|BIR|
|DUF3643|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|spongiotrophoblast layer development|
|Flemming body|
|cysteine-type endopeptidase inhibitor activity|
|ubiquitin conjugating enzyme activity|
|labyrinthine layer development|
|embryonic placenta development|
|regulation of cytokinesis|
|negative regulation of extrinsic apoptotic signaling pathway|
|spindle pole|
|placenta development|
|regulation of extrinsic apoptotic signaling pathway|
|midbody|
|microtubule organizing center|
|regulation of cell division|
|trans-Golgi network|
|negative regulation of apoptotic signaling pathway|
|negative regulation of endopeptidase activity|
|ubiquitin-protein transferase activity|
|negative regulation of peptidase activity|
|endosome|
|negative regulation of proteolysis|
|in utero embryonic development|
|regulation of apoptotic signaling pathway|
|regulation of endopeptidase activity|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|cell division|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|developmental process involved in reproduction|
|protein catabolic process|
|protein ubiquitination|
|regulation of proteolysis|
|regulation of cell cycle process|
|protein modification by small protein conjugation|
|negative regulation of catalytic activity|
|negative regulation of apoptotic process|
|cellular macromolecule catabolic process|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|apoptotic process|
|protein phosphorylation|
|embryo development|
|protein modification by small protein conjugation or removal|
|negative regulation of cell death|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|cell death|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of cell cycle|
|negative regulation of signal transduction|
|proteolysis|
|regulation of hydrolase activity|
|phosphorylation|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|reproductive process|
|reproduction|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of cell death|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-2.26|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.05|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-1.98|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-1.77|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.71|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|1.79|
|[[:results:exp539|42°C R08 exp539]]|1.81|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|1.89|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.89|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.97|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2.05|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|2.07|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|2.12|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|2.23|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.51|
|[[:results:exp292|Menadione 5μM R06 exp292]]|2.73|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|3.6|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|4.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:u:uba6|UBA6]]|0.639|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 18/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|0/28|
|bone|0/26|
|breast|5/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3832
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BIRC6 Expression in NALM6 Cells: 8.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>