BMP2 [The Human Chemical-Genetic Interaction Map Project]

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======= BMP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BMP2
  * **<color #00a2e8>Official Name</color>**: bone morphogenetic protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=650|650]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P12643|P12643]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BMP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BMP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/112261|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451). {ECO:0000269|PubMed:24362451, ECO:0000269|PubMed:3201241}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TGF beta|
|TGFb propeptide|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of Wnt signaling pathway by BMP signaling pathway|
|negative regulation of calcium-independent cell-cell adhesion|
|endodermal-mesodermal cell signaling involved in heart induction|
|BMP receptor complex|
|regulation of calcium-independent cell-cell adhesion|
|endodermal-mesodermal cell signaling|
|heart induction|
|corticotropin hormone secreting cell differentiation|
|BMP signaling pathway involved in heart induction|
|cell proliferation involved in mesonephros development|
|thyroid-stimulating hormone-secreting cell differentiation|
|embryonic heart tube anterior/posterior pattern specification|
|phosphatase activator activity|
|mesenchymal cell proliferation involved in ureteric bud development|
|negative regulation of aldosterone biosynthetic process|
|negative regulation of aldosterone metabolic process|
|negative regulation of cortisol biosynthetic process|
|negative regulation of steroid hormone biosynthetic process|
|negative regulation of Wnt signaling pathway involved in heart development|
|negative regulation of glucocorticoid biosynthetic process|
|negative regulation of glucocorticoid metabolic process|
|negative regulation of insulin-like growth factor receptor signaling pathway|
|regulation of cortisol biosynthetic process|
|regulation of Wnt signaling pathway involved in heart development|
|bone mineralization involved in bone maturation|
|regulation of aldosterone biosynthetic process|
|regulation of aldosterone metabolic process|
|neuroendocrine cell differentiation|
|regulation of glucocorticoid biosynthetic process|
|regulation of glucocorticoid metabolic process|
|regulation of steroid hormone biosynthetic process|
|negative regulation of hormone biosynthetic process|
|cell proliferation involved in kidney development|
|positive regulation of osteoblast proliferation|
|positive regulation of odontogenesis|
|negative regulation of hormone metabolic process|
|BMP receptor binding|
|positive regulation of astrocyte differentiation|
|co-receptor binding|
|adenohypophysis development|
|telencephalon regionalization|
|pathway-restricted SMAD protein phosphorylation|
|negative regulation of alcohol biosynthetic process|
|regulation of odontogenesis of dentin-containing tooth|
|ossification involved in bone maturation|
|organ induction|
|mesenchymal cell proliferation|
|regulation of ketone biosynthetic process|
|bone maturation|
|negative regulation of cardiac muscle cell differentiation|
|pericardium development|
|retinol dehydrogenase activity|
|negative regulation of cardiocyte differentiation|
|animal organ maturation|
|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|
|regulation of osteoblast proliferation|
|regulation of insulin-like growth factor receptor signaling pathway|
|negative regulation of steroid biosynthetic process|
|forebrain regionalization|
|atrioventricular valve morphogenesis|
|negative regulation of steroid metabolic process|
|atrioventricular valve development|
|regulation of odontogenesis|
|regulation of hormone biosynthetic process|
|regulation of astrocyte differentiation|
|positive regulation of p38MAPK cascade|
|developmental induction|
|cardiac epithelial to mesenchymal transition|
|positive regulation of pri-miRNA transcription by RNA polymerase II|
|negative regulation of cardiac muscle tissue development|
|positive regulation of cartilage development|
|positive regulation of phosphatase activity|
|endocardial cushion morphogenesis|
|regulation of animal organ formation|
|regulation of cardiac muscle cell differentiation|
|glandular epithelial cell differentiation|
|negative regulation of striated muscle cell differentiation|
|regulation of hormone metabolic process|
|positive regulation of bone mineralization|
|regulation of heart morphogenesis|
|regulation of p38MAPK cascade|
|pituitary gland development|
|regulation of pri-miRNA transcription by RNA polymerase II|
|positive regulation of glial cell differentiation|
|transforming growth factor beta receptor binding|
|endocardial cushion development|
|neuroepithelial cell differentiation|
|branching involved in ureteric bud morphogenesis|
|protein destabilization|
|positive regulation of biomineral tissue development|
|positive regulation of biomineralization|
|positive regulation of epithelial to mesenchymal transition|
|bone mineralization|
|negative regulation of striated muscle tissue development|
|positive regulation of pathway-restricted SMAD protein phosphorylation|
|negative regulation of muscle organ development|
|negative regulation of lipid biosynthetic process|
|regulation of cardiocyte differentiation|
|mesenchyme morphogenesis|
|negative regulation of muscle tissue development|
|heart valve morphogenesis|
|SMAD binding|
|ureteric bud morphogenesis|
|mesonephric tubule morphogenesis|
|negative regulation of muscle cell differentiation|
|SMAD protein signal transduction|
|positive regulation of dephosphorylation|
|positive regulation of osteoblast differentiation|
|regulation of pathway-restricted SMAD protein phosphorylation|
|positive regulation of fat cell differentiation|
|heart valve development|
|nephron tubule morphogenesis|
|nephron epithelium morphogenesis|
|nephron morphogenesis|
|cardiac muscle tissue morphogenesis|
|renal tubule morphogenesis|
|regulation of glial cell differentiation|
|positive regulation of gliogenesis|
|epithelial to mesenchymal transition|
|regulation of cartilage development|
|regulation of alcohol biosynthetic process|
|regulation of bone mineralization|
|diencephalon development|
|nephron tubule development|
|regulation of cardiac muscle tissue development|
|renal tubule development|
|muscle tissue morphogenesis|
|positive regulation of animal organ morphogenesis|
|chondrocyte differentiation|
|odontogenesis of dentin-containing tooth|
|negative regulation of lipid metabolic process|
|regulation of epithelial to mesenchymal transition|
|kidney morphogenesis|
|positive regulation of ossification|
|ureteric bud development|
|mesonephric epithelium development|
|muscle organ morphogenesis|
|mesonephric tubule development|
|cardiac muscle cell differentiation|
|regulation of steroid biosynthetic process|
|BMP signaling pathway|
|negative regulation of small molecule metabolic process|
|mesonephros development|
|proteoglycan metabolic process|
|biomineralization|
|regulation of biomineral tissue development|
|biomineral tissue development|
|regulation of biomineralization|
|positive regulation of protein binding|
|positive regulation of endothelial cell proliferation|
|columnar/cuboidal epithelial cell differentiation|
|nephron epithelium development|
|regulation of striated muscle cell differentiation|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|response to BMP|
|cellular response to BMP stimulus|
|regulation of osteoblast differentiation|
|regulation of steroid metabolic process|
|regulation of gliogenesis|
|cardiocyte differentiation|
|odontogenesis|
|endocrine system development|
|regulation of fat cell differentiation|
|nephron development|
|Notch signaling pathway|
|osteoblast differentiation|
|regulation of endothelial cell proliferation|
|kidney epithelium development|
|branching morphogenesis of an epithelial tube|
|regulation of striated muscle tissue development|
|anatomical structure maturation|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|regulation of muscle cell differentiation|
|activation of MAPK activity|
|mesenchymal cell differentiation|
|morphogenesis of a branching epithelium|
|cardiac muscle tissue development|
|growth factor activity|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|morphogenesis of a branching structure|
|regulation of cellular ketone metabolic process|
|cartilage development|
|cytokine activity|
|negative regulation of cell-cell adhesion|
|negative regulation of canonical Wnt signaling pathway|
|regulation of phosphatase activity|
|positive regulation of Wnt signaling pathway|
|positive regulation of binding|
|regulation of lipid biosynthetic process|
|positive regulation of epithelial cell proliferation|
|regulation of ossification|
|inner ear development|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|bone development|
|striated muscle cell differentiation|
|negative regulation of Wnt signaling pathway|
|regulation of dephosphorylation|
|positive regulation of ERK1 and ERK2 cascade|
|anterior/posterior pattern specification|
|regulation of protein binding|
|mesenchyme development|
|ear development|
|connective tissue development|
|regulation of stress-activated MAPK cascade|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of stress-activated protein kinase signaling cascade|
|developmental maturation|
|muscle cell differentiation|
|cell fate commitment|
|heart morphogenesis|
|telencephalon development|
|regulation of animal organ morphogenesis|
|positive regulation of MAP kinase activity|
|ossification|
|kidney development|
|negative regulation of cell adhesion|
|regulation of canonical Wnt signaling pathway|
|striated muscle tissue development|
|renal system development|
|regulation of protein stability|
|regulation of ERK1 and ERK2 cascade|
|muscle organ development|
|muscle tissue development|
|epithelial tube morphogenesis|
|urogenital system development|
|activation of protein kinase activity|
|regionalization|
|regulation of epithelial cell proliferation|
|signaling receptor binding|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|response to hypoxia|
|response to decreased oxygen levels|
|regulation of Wnt signaling pathway|
|positive regulation of neuron differentiation|
|regulation of binding|
|in utero embryonic development|
|response to oxygen levels|
|forebrain development|
|glycoprotein metabolic process|
|regulation of lipid metabolic process|
|regulation of cell-cell adhesion|
|gland development|
|regulation of small molecule metabolic process|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|morphogenesis of an epithelium|
|pattern specification process|
|positive regulation of neurogenesis|
|muscle structure development|
|protein heterodimerization activity|
|skeletal system development|
|inflammatory response|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cell motility|
|heart development|
|response to growth factor|
|positive regulation of protein kinase activity|
|regulation of hormone levels|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|cellular response to organic cyclic compound|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|sensory organ development|
|positive regulation of locomotion|
|cell population proliferation|
|tissue morphogenesis|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|cell surface|
|chordate embryonic development|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|positive regulation of transferase activity|
|regulation of neuron differentiation|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|regulation of cell adhesion|
|intracellular membrane-bounded organelle|
|response to bacterium|
|positive regulation of cell death|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|regulation of cellular response to stress|
|brain development|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|head development|
|regulation of protein kinase activity|
|regulation of neurogenesis|
|tube development|
|regulation of cell migration|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|regulation of kinase activity|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|oxidation-reduction process|
|positive regulation of cell differentiation|
|protein phosphorylation|
|embryo development|
|regulation of transferase activity|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|carbohydrate derivative metabolic process|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|cell-cell signaling|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8319
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BMP2 Expression in NALM6 Cells: -1.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>