BMPR1B [The Human Chemical-Genetic Interaction Map Project]

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======= BMPR1B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BMPR1B
  * **<color #00a2e8>Official Name</color>**: bone morphogenetic protein receptor type 1B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=658|658]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00238|O00238]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BMPR1B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BMPR1B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603248|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction. {ECO:0000250|UniProtKB:P36898}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Activin recp|
|Pkinase Tyr|
|TGF beta GS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ovarian cumulus expansion|
|fused antrum stage|
|negative regulation of chondrocyte proliferation|
|mammalian oogenesis stage|
|antral ovarian follicle growth|
|transforming growth factor beta receptor activity, type I|
|HFE-transferrin receptor complex|
|transmembrane receptor protein serine/threonine kinase activity|
|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|transforming growth factor beta-activated receptor activity|
|retinal ganglion cell axon guidance|
|cartilage condensation|
|cell aggregation|
|positive regulation of chondrocyte differentiation|
|growth factor binding|
|positive regulation of cartilage development|
|positive regulation of bone mineralization|
|ovulation cycle process|
|chondrocyte development|
|positive regulation of biomineral tissue development|
|positive regulation of biomineralization|
|positive regulation of extrinsic apoptotic signaling pathway|
|ovarian follicle development|
|regulation of chondrocyte differentiation|
|SMAD binding|
|regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|positive regulation of osteoblast differentiation|
|proteoglycan biosynthetic process|
|ovulation cycle|
|regulation of cartilage development|
|endochondral bone morphogenesis|
|regulation of bone mineralization|
|oogenesis|
|dorsal/ventral pattern formation|
|chondrocyte differentiation|
|positive regulation of ossification|
|female gonad development|
|BMP signaling pathway|
|regulation of biomineral tissue development|
|proteoglycan metabolic process|
|development of primary female sexual characteristics|
|regulation of biomineralization|
|transforming growth factor beta receptor signaling pathway|
|cellular response to BMP stimulus|
|response to BMP|
|female sex differentiation|
|regulation of osteoblast differentiation|
|bone morphogenesis|
|female gamete generation|
|retina development in camera-type eye|
|limb morphogenesis|
|appendage morphogenesis|
|regulation of extrinsic apoptotic signaling pathway|
|cellular response to transforming growth factor beta stimulus|
|response to transforming growth factor beta|
|cartilage development|
|positive regulation of apoptotic signaling pathway|
|limb development|
|appendage development|
|regulation of ossification|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|bone development|
|receptor complex|
|gonad development|
|development of primary sexual characteristics|
|connective tissue development|
|skeletal system morphogenesis|
|germ cell development|
|axon guidance|
|neuron projection guidance|
|sex differentiation|
|rhythmic process|
|camera-type eye development|
|glycoprotein biosynthetic process|
|regionalization|
|cellular process involved in reproduction in multicellular organism|
|eye development|
|visual system development|
|protein serine/threonine kinase activity|
|sensory system development|
|neuronal cell body|
|axonogenesis|
|glycoprotein metabolic process|
|developmental growth|
|growth|
|regulation of apoptotic signaling pathway|
|axon development|
|dendrite|
|reproductive structure development|
|reproductive system development|
|cell morphogenesis involved in neuron differentiation|
|pattern specification process|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|skeletal system development|
|inflammatory response|
|cellular response to growth factor stimulus|
|cell part morphogenesis|
|response to growth factor|
|sensory organ development|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|carbohydrate derivative biosynthetic process|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|neuron projection development|
|developmental process involved in reproduction|
|negative regulation of cell population proliferation|
|gamete generation|
|positive regulation of cell death|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|protein phosphorylation|
|multi-organism reproductive process|
|neuron differentiation|
|carbohydrate derivative metabolic process|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|phosphorylation|
|locomotion|
|defense response|
|positive regulation of developmental process|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|ATP binding|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-1.74|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.8|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.82|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9632
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BMPR1B Expression in NALM6 Cells: -0.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>