BOLL [The Human Chemical-Genetic Interaction Map Project]

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======= BOLL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BOLL
  * **<color #00a2e8>Official Name</color>**: boule homolog, RNA binding protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=66037|66037]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N9W6|Q8N9W6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BOLL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BOLL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606165|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|translation activator activity|
|3-UTR-mediated mRNA stabilization|
|positive regulation of translational initiation|
|mRNA stabilization|
|RNA stabilization|
|negative regulation of mRNA catabolic process|
|negative regulation of RNA catabolic process|
|mRNA 3-UTR binding|
|regulation of translational initiation|
|negative regulation of mRNA metabolic process|
|positive regulation of translation|
|positive regulation of cellular amide metabolic process|
|regulation of mRNA stability|
|regulation of RNA stability|
|regulation of mRNA catabolic process|
|meiotic cell cycle|
|negative regulation of cellular catabolic process|
|germ cell development|
|negative regulation of catabolic process|
|regulation of mRNA metabolic process|
|regulation of translation|
|cellular process involved in reproduction in multicellular organism|
|regulation of cellular amide metabolic process|
|posttranscriptional regulation of gene expression|
|spermatogenesis|
|male gamete generation|
|developmental process involved in reproduction|
|gamete generation|
|multicellular organismal reproductive process|
|sexual reproduction|
|regulation of cellular catabolic process|
|multicellular organism reproduction|
|multi-organism reproductive process|
|regulation of catabolic process|
|negative regulation of RNA metabolic process|
|cell cycle|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|positive regulation of cellular protein metabolic process|
|cell development|
|positive regulation of protein metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-1.91|
|[[:results:exp218|A-395 10μM R05 exp218]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11900
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BOLL Expression in NALM6 Cells: -1.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>