BORA [The Human Chemical-Genetic Interaction Map Project]

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======= BORA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BORA
  * **<color #00a2e8>Official Name</color>**: BORA aurora kinase A activator
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79866|79866]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6PGQ7|Q6PGQ7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BORA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BORA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610510|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for the activation of AURKA at the onset of mitosis. {ECO:0000269|PubMed:16890155}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|meiotic spindle|
|regulation of mitotic spindle organization|
|regulation of spindle organization|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|regulation of mitotic nuclear division|
|regulation of microtubule cytoskeleton organization|
|regulation of nuclear division|
|regulation of microtubule-based process|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|activation of protein kinase activity|
|protein kinase binding|
|cell division|
|positive regulation of protein kinase activity|
|regulation of cytoskeleton organization|
|positive regulation of kinase activity|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|positive regulation of transferase activity|
|mitotic cell cycle|
|regulation of cell cycle process|
|regulation of protein kinase activity|
|regulation of kinase activity|
|regulation of transferase activity|
|cell cycle process|
|positive regulation of protein phosphorylation|
|regulation of protein localization|
|positive regulation of phosphorylation|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of cell cycle|
|positive regulation of protein modification process|
|regulation of organelle organization|
|cell cycle|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-2.32|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.72|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:plk1|PLK1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 432/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|15/28|
|blood|16/28|
|bone|17/26|
|breast|19/33|
|central nervous system|29/56|
|cervix|1/4|
|colorectal|7/17|
|esophagus|6/13|
|fibroblast|1/1|
|gastric|9/16|
|kidney|12/21|
|liver|15/20|
|lung|50/75|
|lymphocyte|9/16|
|ovary|12/26|
|pancreas|16/24|
|peripheral nervous system|13/16|
|plasma cell|10/15|
|prostate|1/1|
|skin|11/24|
|soft tissue|6/9|
|thyroid|2/2|
|upper aerodigestive|13/22|
|urinary tract|17/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2298
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BORA Expression in NALM6 Cells: 5.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>