BRD2 [The Human Chemical-Genetic Interaction Map Project]

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======= BRD2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BRD2
  * **<color #00a2e8>Official Name</color>**: bromodomain containing 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6046|6046]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P25440|P25440]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BRD2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BRD2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601540|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Bromodomain|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lysine-acetylated histone binding|
|nucleosome assembly|
|chromatin assembly|
|chromatin assembly or disassembly|
|nucleosome organization|
|DNA packaging|
|protein-DNA complex assembly|
|protein-DNA complex subunit organization|
|DNA conformation change|
|chromatin binding|
|nuclear speck|
|spermatogenesis|
|male gamete generation|
|gamete generation|
|chromatin organization|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|multicellular organismal reproductive process|
|sexual reproduction|
|cellular protein-containing complex assembly|
|multicellular organism reproduction|
|multi-organism reproductive process|
|chromosome organization|
|reproductive process|
|reproduction|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-3.61|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-3.32|
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.88|
|[[:results:exp539|42°C R08 exp539]]|-2.76|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.69|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.63|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.62|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-2.57|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.44|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-2.34|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-2.33|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.25|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-2.12|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-2.02|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.93|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-1.86|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.86|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.85|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|-1.82|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.81|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.78|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.77|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-1.76|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.71|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|1.74|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.76|
|[[:results:exp114|A-196 10μM R03 exp114]]|1.93|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.96|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|1.99|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.02|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.11|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.15|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|2.31|
|[[:results:exp518|RK-33 8μM R08 exp518]]|2.37|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psmb4|PSMB4]]|0.566|
|[[:human genes:c:chd4|CHD4]]|0.511|
|[[:human genes:t:tgfbrap1|TGFBRAP1]]|0.509|
|[[:human genes:t:taf1|TAF1]]|0.507|
|[[:human genes:n:nelfa|NELFA]]|0.481|
|[[:human genes:p:pan3|PAN3]]|0.477|
|[[:human genes:i:ints5|INTS5]]|0.473|
|[[:human genes:n:nelfb|NELFB]]|0.473|
|[[:human genes:p:pds5b|PDS5B]]|0.47|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.47|
|[[:human genes:c:copg1|COPG1]]|0.469|
|[[:human genes:p:polr2i|POLR2I]]|0.465|
|[[:human genes:e:eif4a3|EIF4A3]]|0.465|
|[[:human genes:p:psma7|PSMA7]]|0.463|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.463|
|[[:human genes:t:tsg101|TSG101]]|0.461|
|[[:human genes:r:rrp7a|RRP7A]]|0.457|
|[[:human genes:r:rpl35|RPL35]]|0.454|
|[[:human genes:r:rpl6|RPL6]]|0.453|
|[[:human genes:u:utp3|UTP3]]|0.453|
|[[:human genes:p:psma6|PSMA6]]|0.453|
|[[:human genes:m:myb|MYB]]|0.453|
|[[:human genes:s:sf3a3|SF3A3]]|0.451|
|[[:human genes:s:sf3a1|SF3A1]]|0.448|
|[[:human genes:n:narfl|NARFL]]|0.445|
|[[:human genes:t:tceb3c|TCEB3C]]|0.445|
|[[:human genes:r:rps19|RPS19]]|0.444|
|[[:human genes:k:kiaa0947|KIAA0947]]|0.444|
|[[:human genes:p:psmd14|PSMD14]]|0.443|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.442|
|[[:human genes:n:nup160|NUP160]]|0.441|
|[[:human genes:g:gid4|GID4]]|0.44|
|[[:human genes:u:ube2q2l|UBE2Q2L]]|0.44|
|[[:human genes:d:dhx38|DHX38]]|0.44|
|[[:human genes:c:copz1|COPZ1]]|0.435|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.434|
|[[:human genes:p:polr2f|POLR2F]]|0.434|
|[[:human genes:e:exosc4|EXOSC4]]|0.434|
|[[:human genes:k:krt2|KRT2]]|0.434|
|[[:human genes:k:kctd17|KCTD17]]|0.433|
|[[:human genes:s:supt5h|SUPT5H]]|0.433|
|[[:human genes:t:taf6|TAF6]]|0.432|
|[[:human genes:n:nip7|NIP7]]|0.431|
|[[:human genes:p:psmb2|PSMB2]]|0.43|
|[[:human genes:p:psmd11|PSMD11]]|0.43|
|[[:human genes:m:mtch2|MTCH2]]|0.427|
|[[:human genes:c:ctr9|CTR9]]|0.423|
|[[:human genes:a:aamp|AAMP]]|0.422|
|[[:human genes:f:fgf13|FGF13]]|0.421|
|[[:human genes:c:cactin|CACTIN]]|0.42|
|[[:human genes:t:terf1|TERF1]]|0.42|
|[[:human genes:s:sf3b2|SF3B2]]|0.419|
|[[:human genes:i:ilf2|ILF2]]|0.417|
|[[:human genes:c:copa|COPA]]|0.417|
|[[:human genes:s:smg1|SMG1]]|0.417|
|[[:human genes:s:slc6a17|SLC6A17]]|0.415|
|[[:human genes:r:rbm39|RBM39]]|0.413|
|[[:human genes:m:mt1e|MT1E]]|0.413|
|[[:human genes:r:rpl8|RPL8]]|0.413|
|[[:human genes:p:pola2|POLA2]]|0.412|
|[[:human genes:n:nelfcd|NELFCD]]|0.411|
|[[:human genes:i:iscu|ISCU]]|0.41|
|[[:human genes:n:npipb5|NPIPB5]]|0.409|
|[[:human genes:a:arcn1|ARCN1]]|0.408|
|[[:human genes:p:paf1|PAF1]]|0.406|
|[[:human genes:r:rrp15|RRP15]]|0.406|
|[[:human genes:r:rpl30|RPL30]]|0.405|
|[[:human genes:i:ints8|INTS8]]|0.405|
|[[:human genes:a:acsf2|ACSF2]]|0.404|
|[[:human genes:r:rps5|RPS5]]|0.403|
|[[:human genes:i:igfn1|IGFN1]]|0.403|
|[[:human genes:d:dtl|DTL]]|0.403|
|[[:human genes:e:exosc5|EXOSC5]]|0.402|
|[[:human genes:s:snrpa1|SNRPA1]]|0.402|
|[[:human genes:p:polr2j3|POLR2J3]]|0.402|
|[[:human genes:v:vasn|VASN]]|0.402|
|[[:human genes:d:ddx56|DDX56]]|0.4|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.4|
|[[:human genes:r:rps12|RPS12]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 35/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|0/28|
|bone|0/25|
|breast|1/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|3/21|
|liver|1/20|
|lung|3/75|
|lymphocyte|4/14|
|ovary|2/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|2/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 982
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BRD2 Expression in NALM6 Cells: 8.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>