BRD9 [The Human Chemical-Genetic Interaction Map Project]

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======= BRD9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BRD9
  * **<color #00a2e8>Official Name</color>**: bromodomain containing 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=65980|65980]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H8M2|Q9H8M2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BRD9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BRD9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618465|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Bromodomain|
|DUF3512|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|SWI/SNF complex|
|lysine-acetylated histone binding|
|nucleic acid binding|
|chromatin organization|
|chromosome organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|-2.17|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:ccdc101|CCDC101]]|0.463|
|[[:human genes:c:cbfb|CBFB]]|0.451|
|[[:human genes:i:id3|ID3]]|0.433|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.43|
|[[:human genes:b:bap1|BAP1]]|0.428|
|[[:human genes:s:ssbp2|SSBP2]]|0.42|
|[[:human genes:m:med23|MED23]]|0.418|
|[[:human genes:d:dohh|DOHH]]|0.412|
|[[:human genes:x:xpo6|XPO6]]|0.412|
|[[:human genes:r:rptor|RPTOR]]|0.411|
|[[:human genes:h:helz|HELZ]]|0.411|
|[[:human genes:n:nsd1|NSD1]]|0.407|
|[[:human genes:m:med16|MED16]]|0.406|
|[[:human genes:l:lsmd1|LSMD1]]|0.401|
|[[:human genes:f:fli1|FLI1]]|0.4|
|[[:human genes:u:ube3a|UBE3A]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1499
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BRD9 Expression in NALM6 Cells: 6.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>