BRIP1 [The Human Chemical-Genetic Interaction Map Project]

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======= BRIP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BRIP1
  * **<color #00a2e8>Official Name</color>**: BRCA1 interacting protein C-terminal helicase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83990|83990]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BX63|Q9BX63]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BRIP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BRIP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605882|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. {ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:14983014, ECO:0000269|PubMed:16116421, ECO:0000269|PubMed:16153896}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DEAD 2|
|DEAD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|meiotic DNA double-strand break processing involved in reciprocal meiotic recombination|
|spermatogonial cell division|
|double-strand break repair involved in meiotic recombination|
|meiotic DNA double-strand break processing|
|chiasma assembly|
|seminiferous tubule development|
|cellular response to angiotensin|
|DNA double-strand break processing|
|cellular response to vitamin|
|response to angiotensin|
|4 iron, 4 sulfur cluster binding|
|synapsis|
|reciprocal meiotic recombination|
|homologous recombination|
|homologous chromosome segregation|
|DNA helicase activity|
|RNA helicase activity|
|chromosome organization involved in meiotic cell cycle|
|cellular response to nutrient|
|response to vitamin|
|meiotic chromosome segregation|
|meiosis I|
|DNA duplex unwinding|
|nucleotide-excision repair|
|meiosis I cell cycle process|
|DNA geometric change|
|DNA damage checkpoint|
|male gonad development|
|development of primary male sexual characteristics|
|DNA integrity checkpoint|
|spermatid development|
|meiotic nuclear division|
|spermatid differentiation|
|male sex differentiation|
|meiotic cell cycle process|
|regulation of signal transduction by p53 class mediator|
|double-strand break repair|
|cellular response to hypoxia|
|cell cycle checkpoint|
|cellular response to decreased oxygen levels|
|gonad development|
|DNA replication|
|cellular response to oxygen levels|
|response to nutrient|
|development of primary sexual characteristics|
|nuclear chromosome segregation|
|DNA recombination|
|meiotic cell cycle|
|cellular response to nutrient levels|
|nuclear membrane|
|germ cell development|
|cellular response to extracellular stimulus|
|sex differentiation|
|cellular response to peptide hormone stimulus|
|chromosome segregation|
|nuclear division|
|DNA conformation change|
|organelle fission|
|cellular response to peptide|
|cellular response to external stimulus|
|response to hypoxia|
|cellular process involved in reproduction in multicellular organism|
|response to decreased oxygen levels|
|response to oxygen levels|
|response to peptide hormone|
|chromatin binding|
|reproductive structure development|
|reproductive system development|
|response to peptide|
|cell division|
|response to nutrient levels|
|response to toxic substance|
|DNA repair|
|response to extracellular stimulus|
|spermatogenesis|
|male gamete generation|
|negative regulation of cell cycle|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|developmental process involved in reproduction|
|negative regulation of cell population proliferation|
|gamete generation|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|response to hormone|
|multi-organism reproductive process|
|cell cycle process|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|chromosome organization|
|response to nitrogen compound|
|response to abiotic stimulus|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|cell cycle|
|reproductive process|
|reproduction|
|DNA binding|
|response to endogenous stimulus|
|ATP binding|
|response to oxygen-containing compound|
|regulation of cell population proliferation|
|cell development|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-3.19|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-2.32|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.31|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|-2.02|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:c17orf70|C17orf70]]|0.468|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1549
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BRIP1 Expression in NALM6 Cells: 6.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>