BRSK1 [The Human Chemical-Genetic Interaction Map Project]

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======= BRSK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BRSK1
  * **<color #00a2e8>Official Name</color>**: BR serine/threonine kinase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84446|84446]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TDC3|Q8TDC3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BRSK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BRSK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609235|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma- tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C. {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15150265, ECO:0000269|PubMed:20026642, ECO:0000269|PubMed:21985311}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|microtubule cytoskeleton organization involved in establishment of planar polarity|
|distal axon|
|regulation of synaptic vesicle clustering|
|mitotic G2 DNA damage checkpoint|
|tau-protein kinase activity|
|establishment of planar polarity|
|establishment of tissue polarity|
|gamma-tubulin binding|
|mitotic G2/M transition checkpoint|
|G2 DNA damage checkpoint|
|centrosome duplication|
|presynaptic active zone|
|morphogenesis of a polarized epithelium|
|tau protein binding|
|associative learning|
|centrosome cycle|
|negative regulation of G2/M transition of mitotic cell cycle|
|microtubule organizing center organization|
|mitotic DNA damage checkpoint|
|negative regulation of cell cycle G2/M phase transition|
|neurotransmitter secretion|
|signal release from synapse|
|mitotic DNA integrity checkpoint|
|regulation of synaptic vesicle cycle|
|establishment of cell polarity|
|synaptic vesicle cycle|
|synaptic vesicle|
|vesicle-mediated transport in synapse|
|DNA damage checkpoint|
|response to UV|
|DNA integrity checkpoint|
|learning|
|response to ionizing radiation|
|mitotic cell cycle checkpoint|
|signal release|
|neurotransmitter transport|
|regulation of axonogenesis|
|regulation of synaptic plasticity|
|cell cycle checkpoint|
|regulation of G2/M transition of mitotic cell cycle|
|establishment or maintenance of cell polarity|
|regulation of cell cycle G2/M phase transition|
|negative regulation of mitotic cell cycle phase transition|
|magnesium ion binding|
|negative regulation of cell cycle phase transition|
|learning or memory|
|cognition|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of mitotic cell cycle|
|response to light stimulus|
|negative regulation of cell cycle process|
|regulation of neurotransmitter levels|
|protein serine/threonine kinase activity|
|axonogenesis|
|axon development|
|regulation of mitotic cell cycle phase transition|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|morphogenesis of an epithelium|
|cell morphogenesis involved in neuron differentiation|
|trans-synaptic signaling|
|response to radiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of cell cycle phase transition|
|synaptic signaling|
|protein kinase binding|
|microtubule cytoskeleton organization|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|centrosome|
|regulation of neuron projection development|
|cell part morphogenesis|
|cell junction|
|regulation of vesicle-mediated transport|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|behavior|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|regulation of neuron differentiation|
|neuron projection development|
|microtubule-based process|
|mitotic cell cycle|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|cell morphogenesis|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|protein phosphorylation|
|cell cycle process|
|secretion by cell|
|neuron differentiation|
|export from cell|
|regulation of anatomical structure morphogenesis|
|cytoskeleton organization|
|epithelium development|
|cell-cell signaling|
|secretion|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|response to abiotic stimulus|
|regulation of cell cycle|
|phosphorylation|
|cell cycle|
|nervous system process|
|ATP binding|
|generation of neurons|
|neurogenesis|
|cell development|
|intracellular signal transduction|
|cellular response to stress|
|tissue development|
|regulation of cell differentiation|
|establishment of localization in cell|
|regulation of transport|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|-2.1|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-2.1|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|-1.92|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-1.81|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-1.81|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.81|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12965
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BRSK1 Expression in NALM6 Cells: 3.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>