BSN [The Human Chemical-Genetic Interaction Map Project]

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======= BSN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BSN
  * **<color #00a2e8>Official Name</color>**: bassoon presynaptic cytomatrix protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8927|8927]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UPA5|Q9UPA5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BSN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BSN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604020|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Neurotransmitters are released from a specific site in the axon terminal called the active zone, which is composed of synaptic vesicles and a meshwork of cytoskeleton underlying the plasma membrane. The protein encoded by this gene is thought to be a scaffolding protein involved in organizing the presynaptic cytoskeleton. The gene is expressed primarily in neurons in the brain. A similar gene product in rodents is concentrated in the active zone of axon terminals and tightly associated with cytoskeletal structures, and is essential for regulating neurotransmitter release from a subset of synapses. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Is thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act through binding to ERC2/CAST1. Essential in regulated neurotransmitter release from a subset of brain glutamatergic synapses. Involved in the formation of the retinal photoreceptor ribbon synapses (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-piccolo|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|presynapse to nucleus signaling pathway|
|presynaptic signal transduction|
|structural constituent of presynaptic active zone|
|maintenance of presynaptic active zone structure|
|cytoskeleton of presynaptic active zone|
|presynaptic active zone organization|
|maintenance of synapse structure|
|neuron projection terminus|
|excitatory synapse|
|presynaptic active zone|
|cellular component maintenance|
|protein localization to synapse|
|GABA-ergic synapse|
|synaptic vesicle membrane|
|Schaffer collateral - CA1 synapse|
|synapse assembly|
|regulation of synaptic vesicle cycle|
|synaptic vesicle|
|postsynaptic density|
|synapse organization|
|axon|
|glutamatergic synapse|
|anterograde trans-synaptic signaling|
|dendrite|
|chemical synaptic transmission|
|trans-synaptic signaling|
|synaptic signaling|
|cell junction|
|regulation of vesicle-mediated transport|
|cell surface|
|regulation of cellular localization|
|cell-cell signaling|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp133|MKC9989 10μM R03 exp133]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10268
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BSN Expression in NALM6 Cells: 1.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>