BTAF1 [The Human Chemical-Genetic Interaction Map Project]

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======= BTAF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BTAF1
  * **<color #00a2e8>Official Name</color>**: B-TFIID TATA-box binding protein associated factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9044|9044]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14981|O14981]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BTAF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BTAF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605191|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box in an ATP-dependent manner.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3535|
|Helicase C|
|SNF2 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of chromatin binding|
|regulation of chromatin binding|
|helicase activity|
|negative regulation of binding|
|regulation of binding|
|DNA-binding transcription factor activity|
|intracellular membrane-bounded organelle|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|1.75|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.84|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.88|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.98|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.07|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|2.17|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.18|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.45|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.72|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|3.21|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|3.7|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|3.97|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|4.43|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fbxo11|FBXO11]]|0.524|
|[[:human genes:d:dr1|DR1]]|0.493|
|[[:human genes:w:wdr24|WDR24]]|0.488|
|[[:human genes:t:tle4|TLE4]]|0.487|
|[[:human genes:m:med23|MED23]]|0.474|
|[[:human genes:r:rptor|RPTOR]]|0.468|
|[[:human genes:m:med13|MED13]]|0.46|
|[[:human genes:u:ube3a|UBE3A]]|0.451|
|[[:human genes:t:thoc6|THOC6]]|0.449|
|[[:human genes:c:casp3|CASP3]]|0.449|
|[[:human genes:e:eny2|ENY2]]|0.443|
|[[:human genes:u:uba3|UBA3]]|0.439|
|[[:human genes:c:ccdc101|CCDC101]]|0.436|
|[[:human genes:g:gfpt1|GFPT1]]|0.431|
|[[:human genes:m:med16|MED16]]|0.427|
|[[:human genes:t:thg1l|THG1L]]|0.411|
|[[:human genes:s:spop|SPOP]]|0.411|
|[[:human genes:n:naa35|NAA35]]|0.409|
|[[:human genes:m:med25|MED25]]|0.408|
|[[:human genes:f:fli1|FLI1]]|0.406|
|[[:human genes:u:ube2g2|UBE2G2]]|0.406|
|[[:human genes:w:wdr59|WDR59]]|0.406|
|[[:human genes:t:tp53|TP53]]|0.405|
|[[:human genes:n:nae1|NAE1]]|0.403|
|[[:human genes:e:eif4e|EIF4E]]|0.403|
|[[:human genes:u:ube2m|UBE2M]]|0.402|
|[[:human genes:h:hdac8|HDAC8]]|0.402|
|[[:human genes:m:mtor|MTOR]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 7/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|1/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 571
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BTAF1 Expression in NALM6 Cells: 8.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>